Describe the features of competitive receptor antagonism
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- What are the advantages and disadvantages of receptor adaptation to an organism?Estimate the binding affi nity of a ligand for its receptor from the followingdata:A ligand binds two different receptors with a Kd value of 10−7 M for receptor 1 and a Kd value of 10−9 M for receptor 2. For which receptor does the ligand show the greater affinity? Calculate the fraction of receptors that have a bound ligand ([RL]/RT) in the case of receptor 1 and receptor 2 if the con- centration of free ligand is 10−8 M.
- What is the connection between the absence of HGPRT activity and the behavior al characteristic s of Lesch-Nyhan syndrome?Describe the process and results of receptor-ligand binding.To maximize the activity of an α4β2 nicotinic Achtylchcholine Receptor (nAChR), how many agonist binding sitea should be occupied?
- Describe one type of receptor1. Explain Judith Jarvis Thomson's violinist analogy, what does see think this analogy shows? Address at least one counter argument and her response to it.Compare and contrast the difference between top-down vs. bottom-up regulation in a bullet-point list, table, or some other representation.