Determine the nucleophile and electrophile in this reaction. lucer and aslx, the willow family of plants, was derived fromextracts. In folk medicine, willow bark teas were used as headache remedies and othertonics. Nowadays, salicylic acid is administered in the form of aspirin which is less irritating to thestomach than salicylic acid. To prepare aspirin, salicylic acid is reacted with an excess of aceticanhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In thisexperiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched withthe addition of water. The aspirin product is not very soluble in water so the aspirin product willprecipitate when water is added. The synthesis reaction of aspirin is shown below:HO.+ H3CH3PO4но.H3C OHCH3HO.salicylic acid(C,H,O)acetic anhydride(C,H0,)acetic acid(CH,0,)o=CCH3acetylsalicylic acid(CH,0)102 g/ mol138 g/mold = 1.08 g/mL180 g/molSince acetic acid is very soluble in water, it is easily separated from the aspirin product. The aspirinisolated in this step is the "crude product". A "purified product" can be obtained throughrecrystallization of the crude product in hot ethanol. In this experiment, the crude product will be thedesired product. The percent yield of the crude product will be determined for this reaction. The purityof the product will also be analyzed, The product will be analyzed by three different methods: melting

Given reaction is acetyl salicylic acid synthesis from salicylic acid and acetic anhydride.

Answered: Determine the nucleophile and…

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Determine the nucleophile and electrophile in this reaction.

Chemistry by OpenStax (2015-05-04)

1st Edition

ISBN:9781938168390

Author:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Publisher:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Chapter14: Acid-base Equilibria

Section: Chapter Questions

Problem 26E: Explain why the neutralization reaction of a strong acid and a weak base gives a weakly acidic...

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Question

Determine the nucleophile and electrophile in this reaction.

lucer and as
lx, the willow family of plants, was derived from
extracts. In folk medicine, willow bark teas were used as headache remedies and other
tonics. Nowadays, salicylic acid is administered in the form of aspirin which is less irritating to the
stomach than salicylic acid. To prepare aspirin, salicylic acid is reacted with an excess of acetic
anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this
experiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched with
the addition of water. The aspirin product is not very soluble in water so the aspirin product will
precipitate when water is added. The synthesis reaction of aspirin is shown below:
HO.
+ H3C
H3PO4
но.
H3C OH
CH3
HO.
salicylic acid
(C,H,O)
acetic anhydride
(C,H0,)
acetic acid
(CH,0,)
o=C
CH3
acetylsalicylic acid
(CH,0)
102 g/ mol
138 g/mol
d = 1.08 g/mL
180 g/mol
Since acetic acid is very soluble in water, it is easily separated from the aspirin product. The aspirin
isolated in this step is the "crude product". A "purified product" can be obtained through
recrystallization of the crude product in hot ethanol. In this experiment, the crude product will be the
desired product. The percent yield of the crude product will be determined for this reaction. The purity
of the product will also be analyzed, The product will be analyzed by three different methods: melting

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