Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromosomes a. die by apoptosis in the bone marrow b. will rearrange heavy-chain loci multiple times until a productive rearrangement is made c. undergo clonal proliferation d. upregulate expression of transcription factors E2A and EBF e. fail to rearrange V to DJ.

Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromosomes a. die by apoptosis in the bone marrow b. will rearrange heavy-chain loci multiple times until a productive rearrangement is made c. undergo clonal proliferation d. upregulate expression of transcription factors E2A and EBF e. fail to rearrange V to DJ.

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter17: The Immune System And Disease

Section: Chapter Questions

Problem 3ACQ: Figure 17.17 The Rh antigen is found on Rh-positive red blood cells. An Rh-negative female can...

See similar textbooks

Similar questions

A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement.
If a mature B cell under goes class, which in which domains will change Which of the following regions may change due to somatic hypermutation of the DNA in a mature B cell after it has be activated by antigen? Indicate an/all correct answers • A. CDR 1 B. CDR2 c. CDR3 D. none of the above
Tuberculosis is a chronic respiratory condition caused by Mycobacterium tuberculosis, a high contagious bacterium. People with tuberculosis will often have a persistent (sometimes bloody) cough, fatigue, weight loss, and fever. M. tuberculosis produces a protein we will call “X”. A new test for tuberculosis checks for X antibodies in a person’s blood. If the antibodies are present, the result is “positive.” Why would X antibodies be present in someone’s blood? What specific kind of cells would produce them?
During removal of cancerous tissue in breast cancer, lymph nodes in the armpit are also removed (if found cancerous). As a result, a. cancer will reoccur at the original site b. Breast tissue will remain free of cancer, but remaining lymph nodes will become cancerous c. Lymph nodes will remain free of cancer, but remaining breast tissue will become cancerous d. There will recurrent infections in the associated arm e. There will recurrent infections in opposite arm
Figure 17.17 The Rh antigen is found on Rh-positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?
True of false: 1. Erythocytes can help clear immune complexes by delivering them to macrophages in the spleen and liver for destruction. 2. Activated-induced cytidine deaminase (AID) is necessary for both somatic hypermutation and isotype switching. 3. During affinity maturation germinal center B cells receive a survival signal only if its BCR binds with higher affinity to antigen on the follicaulr dendritic cells after undergoing somatic hypermutation.
All of the following contribute to the establishment and maintenance of long-lived memory B cells except _____. a. replenishment of memory population by cell division b. isotype switching c. somatic hypermutation d. long-term persistence of antigen after primary immune response e. interaction with stromal cells in the bone marrow.
Multiple Matching. Place all possible matches in the spaces at theleft of each Ig.__________IgG__________IgA__________IgD__________IgE__________IgM a. found in mucous secretionsb. a monomerc. a dimerd. has greatest number of Fabse. first antibody made duringthe primary response f. first antibody made duringthe secondary responseg. crosses the placentah. fixes complementi. involved in allergic reactionsj. primarily a surface receptoron B cells
At what stage of B cell development are autoreactive cells removed? A. stem cell stage B. pro-B cell stage C. early pre-B cell stage D. late pre-B cell stage E. immature cell stage
Loss-of-function mutations in the common γ chain (γc) gene are particularly damaging to the immune system because _____. a. homozygotes and heterozygotes fail to make sufficient γc protein for lymphocyte activation b. T cells fail to develop in the thymus c. T-cell dependent and T-cell independent B-cell responses are inhibited d. multiple cytokine receptors cannot signal e. MHC class II genes are unable to be expressed.
_______ involves successive rearrangement at the lightchain loci when reactivity to self antigen occurs during B-cell development. a. receptor editing b. somatic hypermutation c. chromosomal translocation d. clonal deletion e. anergy.
Production of autoantibodies may be due toa. emergence of forbidden clones of B cellsb. production of antibodies against sequestered tissuesc. infection-induced change in receptorsd. All of these are possible.