Development of the nematode Caenorhabditis ele-gans generates exactly 959 somatic cells; it also producesan additional 131 cells that are later eliminated by apop-tosis. Classical genetic experiments in C. elegans isolatedmutants that led to the identification of the first genesinvolved in apoptosis. Of the many mutations affectingapoptosis in the nematode, none have ever been found inthe gene for cytochrome c. Why do you suppose that sucha central effector molecule in apoptosis was not found inthe many genetic screens for “death” genes that have beencarried out in C. elegans?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter29: Transcription And The Regulation Of Gene Expression
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Development of the nematode Caenorhabditis ele-
gans generates exactly 959 somatic cells; it also produces
an additional 131 cells that are later eliminated by apop-
tosis. Classical genetic experiments in C. elegans isolated
mutants that led to the identification of the first genes
involved in apoptosis. Of the many mutations affecting
apoptosis in the nematode, none have ever been found in
the gene for cytochrome c. Why do you suppose that such
a central effector molecule in apoptosis was not found in
the many genetic screens for “death” genes that have been
carried out in C. elegans?

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