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Do you think the hydrolysis GTP and ATP are similar? Explain why or why not?
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- Why can we say that production of a GTP is equivalent toproduction of an ATP?Why does CTP favor the T state while ATP favors the R state? (in reference to CTPase).Why does a phosphorylation/dephosphorylation system allow more sensitive regulation of a metabolic process than a simple allosteric system?
- Is amino acid activation energetically favored? Why or why not?What is the smallest number of molecules of ATP and GTP consumed in the synthesis of a 200- residue protein, starting from amino acids? Assume that the hydrolysis of PP i is equivalent to the hydrolysis of ATP for this calculation.Why might a general ATP-binding inhibitor be a bad idea? Was this a problem with the drug that was developed?
- The text states that ATP is synthesized primarily by energy metabolism,whereas other nucleoside triphosphates are formed from the action of nucleoside diphosphate kinase. What additional pathway exists for GTP synthesis?Whatis the main idea behind the conformational coupling mechanism for ATP synthase? Describe the three conformational states.Do you think that catalase should be able to attach to other substrates besides H2O2? Why or why not?