Donor sheep's mammary cell Is extracted and grown In a tissue culture flask. Another sheep's unfertillized egg is extracted, and the nucleus Is removed. Mammary cell Nucleus Unfertilized egg Donor sheep The cells are fused together with electrical pulses. Mammary cell Egg with nucleus removed The donor nucleus from the mammary cell and the maternal protelns within the enucleated egg Initlate development of the egg Into an embryo. The embryo Is transferred Into a surrogate ewe. Surrogate ewe Allow pregnancy to proceed. A lamb genetically Identical to the donor sheep Is then born. FIGURE 22.6 Protocol for the successful cloning of a sheep. Genes-Traits Dolly was genetically identical to the sheep that donated a mammary cell to create her. Dolly and the donor sheep were genetically identi- cal in the same way that identical twins are; they carried the same set of genes and looked remarkably similar. However, they may have had minor genetic dif- ferences due to possible variation in their mitochondrial DNA and may have ex- hibited some phenotypic differences due to maternal effect or imprinted genes.

Donor sheep's mammary cell Is extracted and grown In a tissue culture flask. Another sheep's unfertillized egg is extracted, and the nucleus Is removed. Mammary cell Nucleus Unfertilized egg Donor sheep The cells are fused together with electrical pulses. Mammary cell Egg with nucleus removed The donor nucleus from the mammary cell and the maternal protelns within the enucleated egg Initlate development of the egg Into an embryo. The embryo Is transferred Into a surrogate ewe. Surrogate ewe Allow pregnancy to proceed. A lamb genetically Identical to the donor sheep Is then born. FIGURE 22.6 Protocol for the successful cloning of a sheep. Genes-Traits Dolly was genetically identical to the sheep that donated a mammary cell to create her. Dolly and the donor sheep were genetically identi- cal in the same way that identical twins are; they carried the same set of genes and looked remarkably similar. However, they may have had minor genetic dif- ferences due to possible variation in their mitochondrial DNA and may have ex- hibited some phenotypic differences due to maternal effect or imprinted genes.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 11QP: A spermatogonial cell undergoes mitosis before entering the meiotic cell cycle en route to the...

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