Draw a formula for Thr-Ala-Ala (T-A-A) in its predominant ionic form at pH 7.3. You may assume for the purposes of this question that the pKa values of the acidic groups ofamino acid residues in the peptide are the same as in the amino acid itself.O• You do not have to consider stereochemistry.• You do not have to explicitly draw H atoms.• Do not include lone pairs in your answer. They will not be considered in the grading.09.05- [ ]ChemDoodleⓇ Draw a formula for Ala-Gln-Asp (A-Q-D) in its predominant ionic form at pH 7.3. You may assume for the purposes of this question that the pKa values of the acidic groupsof amino acid residues in the peptide are the same as in the amino acid itself.• You do not have to consider stereochemistry.• You do not have to explicitly draw H atoms.• Do not include lone pairs in your answer. They will not be considered in the grading.=ChemDoodleⓇ

Here we are required to draw the structure of peptide predominant at pH 7.3

Draw a formula for Thr-Ala-Ala (T-A-A) in its predominant ionic form at pH 7.3. You may assume for the purposes of this question that the pKa values of the acidic groups of amino acid residues in the peptide are the same as in the amino acid itself. • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. 0.85 Po 24 On [F ChemDoodleⓇ

Draw a formula for Thr-Ala-Ala (T-A-A) in its predominant ionic form at pH 7.3. You may assume for the purposes of this question that the pKa values of the acidic groups of amino acid residues in the peptide are the same as in the amino acid itself. • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. 0.85 Po 24 On [F ChemDoodleⓇ

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.SE: Something Extra

Problem 50AP: The -helical parts of myoglobin and other proteins stop whenever a proline residue is encountered in...

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Hemoglobin A has a pI value of 5.6 whereas the variant hemoglobin M has an aspartate residue in place of the normal valine at position 85 of the alpha chain. What effect will this substitution have on the electrophoretic behavior of the protein at pH 7.0. (explain clearly the reason for your answer)
How does the shape of a titration curve confirm the fact that the pH region of greatest buffering power for an amino acid solution is around its pK's? Name four factors (bonds or other forces) that contribute to stabilizing the native structure of a protein, and describe one condition or reagent that interferes with each type of stabilizing force. Why is silk fibroin so strong, but at the same time so soft and flexible?
If the pH of a solution of Arginine is equal to a half of the 3 pka values of all of its functional groups, what will be the charge on the majority of the Arg molecules in that solution? Please explain. Am i supposedd to add up the three pka values and then divide it in half to find the pH? Thanks
The -helical parts of myoglobin and other proteins stop whenever a proline residue is encountered in the chain. Why is proline never present in a protein helix?
An amino acid mixture of phenylalanine, glycine and glutamic acid is to be separated bypaper chromatography. The solvent is less polar than water. Which of these amino acids will have the highest Rf value and which the lowest? Explain. Treatment of a new protein with dansyl chloride reveals two (2) dansyl-labelled derivatives of amino acids, alanine and methionine. What can you deduce about the structure of the protein from these results? Name the amino acids that contribute atoms to both purine and pyrimidine rings.
A typical amino acid with one amino group and one carboxylic acid group, such as serine can exist in water in several iconic forms. Suggest the forms of the amino acid at low pH and at a high pH. Amino acids generally have two pKa values, one in the range of 2 to 3 and the other in the range of 9 to 10. Serene, for example, has pKa values of 2.91 and 9.21. Using species such as acetic acid and ammonia as models, suggest the origin of the two pKa values. Glutamic acid is an amino acid that has three pKa’s: 2.10, 4.07, and 9.47. Draw the structure of glutamic acid and assign each pKa to the appropriate part of the molecule. An unknown amino acid is titrated with strong base, producing the following titration curve. Which amino acid are likely candidates for the unknown?
Asparagine and glutamine residues in proteins are deamidated in an aqueous solution to yield aspartate and glutamate, respectively, and ammonium. Proteins undergoing deamidation of one or more of their Asn or Gln groups have been detected by isoelectric focusing. Why would isoelectric focusing be effective in separating deamidated from non-deamidated protein? Compare the relative pI values of the deamidated and non-deamidated proteins.
Finally, you want to make completely certain that you purified the correct protein and not some other protein (like biochemisnotfunase). To confirm the identity of your protein, you run a Western blot. When doing a Western, one typically needs a solution of phosphate-buffered saline, which is comprised of 10 mM phosphate buffer(pH 8.0) and 0.9% (w/v) NaCl. Describe how you would make 500 mL of this solution including the grams of sodium phosphate, monobasic and sodium phosphate, dibasic that you would need. Making the phosphate buffer is a little tricky. Be sure to use the correct ratio of monobasic and dibasic sodium phosphate to get the correct pH. The Henderson- Hasselbalch equation might come in handy here. Finally, the molecular weight of sodium phosphate, monobasic (NaH2PO4) is 119.98 g/mol and the molecular weight of sodium phosphate, dibasic (Na2HPO4) is 141.96 g/mol.
What are the net charges of the following five-amino-acids peptides at pH 14.0 RRKKQ? (please provide detailed step-by-step solution) 1. Draw detailed structures of the 5-amino-acids peptides 2. Identify pKa values of all ionizable functional groups
His-Met-Asp-Tyr-Phe-Ser Calculate an approximate pI (isoelectric point) for this peptide.
Q1)In the pH range 1.82 to 8.99, H2Arg+ is the principal form of arginine. Which is the second most prominent species at pH 6.0? At pH 5.0?Q2) (a) Draw the structure of the predominant form (principal species) of 1,3-dihydroxybenzene at pH 9.00 and at pH 11.00.(b) What is the second most prominent species at each pH?(c) Calculate the percentage in the major form at each pH
1. Taking the structure of the amino acids into account, give a comparative discussion pK values where histidine=2 and alanine=2.