Answered: Duchenne Muscular Dystrophy (DMD) is a…

Biology: The Unity and Diversity of Life (MindTap Course List)

14th Edition

ISBN:9781305073951

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter8: Dna Structure And Function

Section: Chapter Questions

Problem 1SQ: Which is not a nucleotide base in DNA? a. adenine b. guanine c. glutamine d. thymine e. cytosine f....

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Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA.

From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein.

Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.

Mutation 1:

Position -6

Healthy individual A

Affected brother C

Group of answer choices

A. Normal mRNA, normal protein

B. No mRNA produced (promoter affected)

C. Abnormal mRNA, affected protein

D. Normal mRNA, affected protein

Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.

Mutation 1
Mutation 2
Mutation 4
Mutation 3
-6
500
1235
1535
Healthy
5'
Individual
3'.
A
AGG
TTT
G
-6
500
1235
1535
5' Affected
brother
3'
C
AGC
ATT
A

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