During certain stages of development, the requirement forcertain gene products may require gene amplification. Whatpurpose does gene amplification serve?
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During certain stages of development, the requirement for
certain gene products may require gene amplification. What
purpose does gene amplification serve?
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- During certain stages of cell growth, the requirement for certain gene products may require gene amplification. What purpose does gene amplification serve?What is the advantage and disadvantage of gene repression in development and What does it mean when we say "enhancers work in a combinatorial fashion?Describe in detail the role of super-enhancers. Give some examples. How the super-enhancers can be identified?
- Explain in detail the role of super-enhancers. Give some examples. How the super-enhancers can be identified?Why are regulatory mutations at the mouse Sonic hedgehog gene dominant and viable? Why do coding mutations cause more widespread defects?What are induced pluripotent stem cells? How are they derived from adult somatic cells?
- In the sea urchin, early development may occur even in the presence of actinomycin D, which inhibits RNA synthesis. However, if actinomycin D is present early in development but is removed a few hours later, all development stops. In fact, if actinomycin D is present only between the sixth and eleventh hours of development, events that normally occur at the fifteenth hour are arrested. What conclusions can be drawn concerning the role of gene transcription between hours 6 and 15?Where do enhancers bind? Are enhancers gene specificHow do the ENCODE data vastly help determine which enhancers regulate which genes?
- How 6mA controls gene expression ?Based on Figure 14-14 and the features of ultraconservedelements, what would you predict you’d observe if youinjected a reporter-gene construct of the rat ortholog ofthe ISL1 ultraconserved element into fertilized mouseoocytes and examined reporter gene expression in thedeveloping embryo?An enhancer is surrounded by four genes (A, B, C, and D), as shown in the accompanying diagram. An insulator lies between gene C and gene D. On the basis of the positions of the genes, the enhancer, and the insulator, the transcription of which genes is most likely to be stimulated by the enhancer? Explain your reasoning.