Explain in Biochemistry concepts like folding, and amino acids, enzyme reaction of MPro enzyme in connection to its role with the COVID-19 virus.
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Explain in Biochemistry concepts like folding, and amino acids, enzyme reaction of MPro enzyme in connection to its role with the COVID-19 virus.
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- How the use of the nucleic acid vaccine gives protection against diseases like COVID-19. Please briefly explain at your own words.? explain do it seriouslyDescribe and explain the difference in results if the serial dilution step of the T4 bacteriophage suspension inour experiment was skipped (i.e., all of Step #3 of the procedures was skipped)? _________________________Current EventsThe Johnson and Johnson COVID-19 vaccine consists of inactivated adenovirus that has been altered to containgenetic information encoding SARS-CoV-2 surface spike proteins. The virus targets and delivers this geneticinformation to the cells of our respiratory tract, which produce benign SARS-CoV-2 surface spike proteins butare effective for training our immune system to defend us against SARS-CoV-2.Based on this information and your knowledge of viruses in general, could T4 bacteriophage be used in place ofWhich of the following statement is false regarding the SARS-CoV-2 protease Mpro? a) Mpro catalyze the translation of viral RNA into polyproteins b) Mpro is an ideal drug target because its structure is largely conserved across the SARS-CoV family c) N3 is an irreversible inhibitor that block the substrate binding site of Mpro d) Mpro forms a dimeric structure and each protomer is composed of three domains
- How the use of the nucleic acid vaccine gives protection against diseases like COVID-19. Please briefly explain at your own words.How the use of the nucleic acid vaccine gives protection against diseases like COVID-19. Please explain it?In the treatment of acquired immunodeficiency syndrome (AIDS), a possible mode of therapy is to inhibit the reverse transcriptase (RT) of the human immunodeficiency virus (HIV), whcih is required for the retrovirus to be propogated by RNA-directed DNA synthesis. In the figure below, one of the substrates for RT is thymidine; and two drugs, AZT and HBY097 are known to inhibit HIV RT> (a) Thymidine; (b) AZT; (c) HBY097 Look at the structures and predict the type of inhibition (i.e. competitive or non-competitive) likely to be shown by each drug. By using knowledge on enzyme, plan an experiment that would enable you to confirm the type of inhibition by investigating enzyme kinetics and explain how you would interpret the results.Remarks: Not more than 250 words.
- Part A What kind of inhibition is imposed on HIV protease by ritonavir? O irreversible inhibition O reversible inhibition O uncompetitive inhibition. Submit Request AnswerList three differences between the structure of HIV and the virus that causes influenza. For one of these differences, explain how the STRUCTURE is key to the FUNCTION of the virus.Palivizumab is a humanized monoclonal anitbody for the prohylaxis of resporatory diseases caused by respiratory syncytical virus (RSV) Researches added palivizumab ( or anitbody 101F as positive control) to RSV prior to incubation with human cells. Based on what you learned about palivizumab what does the data recorded below demonstrate about palivizumab mechanism of action?
- Explain how a frameshift in reading mRNA affects the translation of the mRNA for the IAV viral proteaseName a nucleoside analog. Explain how that nucleoside analog works. Which viruses are effectively treated by that nucleoside analog?Azidothymidine is a Thymidine analog used to inhibit viral reverse transcriptase. Explain the application of this nucleoside analog as an antiviral drug and how it affects reverse transcription and therefore block the ability of the virus to hijack the host cell