Explain the major step of a nucleophilic acyl substitution ?

Q: SCH3 OCH3 Br N(CH3)2 1 2 3 A) 3>1> 2>4 B) 3> 2>1>4 C) 4 > 2 > 3 >1 D) 1>3> 2 > 4

A: Order the carboxylic acid derivatives from most reactive to least reactive towards nucleophilic…

Q: Summarize the main characteristics of nucleophilic acyl substitution

A: Nucleophilic acyl substitution reaction is a special type of substitution reaction which occurs…

Q: Complete the following synthesis schemes. Some may take more than one step and some may have several…

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Q: Rank the following compounds in order of increasing reactivity towards nucleophilic attack.

A: A nucleophile attacks an electrophile in a reaction.

Q: Select the major product in the following reaction.

A: Solution: We know tertiary butoxide is a strong hindered base. Given substrate is tertiary alkyl…

Q: Explain why acetals do not react with nucleophiles.

A: Nucleophiles are electron-rich species. They have tendency to donate electron density. If any other…

Q: What is the major product formed by an intramolecular Friedel–Crafts acylation of the following…

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Q: What site on the alkyl halide is likely to get attacked by the cyanide (in other words, which atom…

A: Electrophilic sites are those sites which are electron deficient.

Q: Explain the Mechanism of Tautomerization ?

A: In this question, we will explain the mechanism of Tautomerization.  You can see details explanation…

Q: Indicate the reagent needed for the below reaction: н он

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Q: Which pair of compounds would be synthetically useful when treated with NaOH? CHO

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Q: Choose the most correct set of reagents for the following reaction.

A: Alcohol can be converted into the ether by a nucleophilic substitution reaction mechanism. In the…

Q: Rank the following according to increasing reactivity with 1 as the least reactive, and 4 as the…

A: The reactivity order for nucleophilic acyl substitution is as follows:

Q: Draw a stepwise mechanism for the following Robinson annulation. This reaction was a key step in a…

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Q: Devise a synthesis of attached compound from the indicated starting material.

A: The starting material of the synthesis of compound is phenol. The structure of the final product…

Q: Explain the general reaction of enolates—reaction with other carbonyl compounds ?

A: Applying concept of aldol reaction.

Q: . Like acid chlorides, acid anhydrides react with alcohols in the presence of pyridine to form…

A: We will write the nucleophile, electrophile, base and tetrahedral intermediate. Then we will draw…

Q: Which carbon will be the best site for electrophilic aromatic substitution? A C

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Q: Explain the Synthesizing an Ether by a Two-Step Reaction Sequence ?

A: The two-step reaction sequence for the synthesis of ether is known as the Williamson synthesis of…

Q: Describe the mechanism step of this reaction below: H3O* OEt Explain the reason of the nucleophilic…

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Q: Label the electrophilic and nucleophilic sites in each molecule.

A: A nucleophile is defined as an electron rich species. It is also known as "nucleus loving" or…

Q: Shown below is the tetrahedral intermediate in a nucleophilic acyl substitution reaction. Draw the…

A: In this equation, we want to draw starting material ( carbonyl reactant ) on left side box and also…

Q: Explain the Process of Determining the Mechanism of Nucleophilic Substitution ?

A: In organic chemistry, a kind of chemical reaction where a nucleophile gets bonded to atoms (or)…

Q: Explain Reaction of Acetylide Anions with Alkyl Halides ?

A: Alkyl halides react with acetylide ions and as acetylide ions are strong base and strong…

Q: Acetanilide is less reactive than aniline toward eletrophilic substitution. Explain.

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Q: Select the major product of the following reaction.

A: Electrophilic addition reactions (EAR):  In general alkenes undergo electrophilic addition…

Q: Draw the product of the reaction and explain the reason OMe

A: Pericyclic reactions are proceeds by a cyclic shift of electrons by a single-step reaction…

Q: Draw the major product of the following reaction. Assume that water is the solvent.

A: The reaction given is,

Q: Draw the major product(s) of nitration of benzoic acid.

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Q: How can this product be synthesized via a Michael reaction.

A: Addition of active CH group at α,β-unsaturated carbonyl, cyano, ester, nitro compounds in basic…

Q: III IV

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Q: D1. What is the major organic product from the OH following reaction?

A: An organic reaction where a nucleophile attacks at an electrophilic center and replaces one of the…

Q: What neutral nucleophile is needed to convert dihalide A to ticlopidine, an antiplatelet drug used…

A: The ticlopidine is framed by supplanting one of the Cl with a nucleophile.  Also, the nucleophile…

Q: Consider carbonyl compounds A–E drawn below. (a) Rank A–E in order of increasing stability. (b) Rank…

A: Introduction: The stability of the carbonyl compound can be determined by the electrophilic…

Q: LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?

A: The full form of LDA is Lithium diisopropylamide. It has isopropyl groups create hindrance and make…

Q: Explain Claisen reaction ?

A: In organic chemistry, the Claisen reaction is a coupling reaction where the carbon-carbon bond…

Q: Why is the carbon bonded to halogen electrophilic? Indicate with arrows the direction of…

A: Carbon is less electronegative than halogen atom.  Halogen atom has greater tendency to attract…

Q: Explain the mechanism for nucleophilic acyl substitution ?

A: Nucleophilic substitution is the reaction of an electron pair donor, nucleophile. In nucleophilic…

Q: Ethers are oxidized with O2 to form hydroperoxides that decompose violently when heated. Draw a…

A: The above reaction takes place via a free radical mechanism.

Q: order the following carbonyl groups in terms of reactivity with nucleophiles (least reactive first)…

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Q: Benzoyl chloride undergoes nucleophilic substitution at a faster rate than methyl propanoate because

A: Nucleophilic attacks on both benzoyl chloride and methyl propanoate are examples of nucleophilic…

Q: What will happen if a carboxylic acid reacts with a Grignard reagent? Draw and explain the…

A: The mechanism is as follows:

Q: What reactant can be used to make this compound by an intramolecular aldol reaction? (A) (B) (C) (D)…

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Q: Could you explain the main characteristics and occurences in nucleophilic acyl substitution? Thank…

A: Nucleophilic acyl substitution describe a class of substitution reaction involving nucleophiles and…

Q: 1. Rank the following according to increasing reactivity (1 - least reactive, 4 - most reactive in a…

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Q: I

A: The nucleophilic addition reaction are those reaction in which a nucleophile attacks on an…

Q: Determine whether attached nucleophilic acyl substitution is likely to occur.

A: Nucleophilic substitution reaction involves the substitution of a leaving group by a nucleophile.…

Q: Which is a reasonable intermediate in an aldol reaction of propanal?

A: In aldol condensation two carbonyl molecules condensed to form betahydroxyaldehyde or…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.