Explain The problem of pleiotropic or redundant genes?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations
Section: Chapter Questions
Problem 24QP: A geneticist discovers that a girl with Down syndrome has a Robertsonian translocation involving...
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Explain The problem of pleiotropic or redundant genes?

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Step 1 Pleiotropic

Pleiotropy can be defined as the phenomenon of a single gene that is responsible for affecting multiple traits.  There has been a long role played that can be understood as the central role in theoretical, experimental, and clinical research as well as In the field of genetics, development, molecular biology, evolution, and medicine.  As per the contemporary situation, genomic techniques have generated data to bear fundamental questions related to the nature and extent of pleiotropy.

The affection of Genes can be understood as a human genetic disorder that is often considered as pleiotropic. For example, people with the hereditary disorder Marfan syndrome may have a  collection of seemingly unrelated symptoms.

  • Unusually tall height
  • Thin fingers and toes
  • Dislocation of the lens of the eye
  • Heart problems (in which the aorta, the large blood vessel carrying blood away from the heart, bulges or ruptures).

The symptoms directly don't appear that are related to one another, on the other hand as it turns out, they can all be traced back to the mutation of a single gene. This gene encodes a protein that assembles into chains, making elastic fibrils that give strength and flexibility to the body’s connective tissues.

 

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