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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 6, Problem 24QP
Textbook Problem
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A geneticist discovers that a girl with Down syndrome has a Robertsonian translocation involving chromosomes 14 and 21. If she has an older brother who is phenotypically normal, what are the chances that he is a translocation carrier?

Summary Introduction

To determine: The chances of a phenotypically normal male being a translocation carrier if the sister with Down syndrome has a Robertsonian translocation involving chromosome 14 and 21.

Introduction: Robertsonian translocations are translocations involving acrocentric chromosomes. During the translocation, the longer arms of the two chromosomes fuse to create one larger chromosome with a centromere in the center. The smaller arms join to form a mini DNA segment with few genes. This translocation changes the chromosome number.

Explanation of Solution

Translocation is a phenomenon which involves the movement of a part of the chromosome to another nonhomologous chromosome. There is no net loss or gain of genetic information from the cell due to translocations. Down syndrome may involve a Robertsonian translocation between chromosome 14 and 21, causing the centromeres to fuse and short arms being lost. The translocation carriers are phenotypically normal, though they are aneuploid.

During meiosis, the carrier will produce six types of gametes...

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