Explain why in human families, many traits (albinism, phenylketonuria, blue eyes ) skip a generation while traits such as polydactyly, free earlobes and A and B blood groups do not.
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Explain why in human families, many traits (albinism, phenylketonuria, blue eyes ) skip a generation while traits such as polydactyly, free earlobes and A and B blood groups do not.
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- Given the following pedigree (note that C7C, M4C, N2X, H6C, G9X, J1C, B8X, and P2X are the names of animals): Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?Two average sized parents have three children. The first child is very short, the second child is very tall, and the third child is average sized. Explain how quantitative genetics could explain the inheritance pattern of height in this pedigree. Explain how it is possible for these parents to have both a very short and a very tall child.
- . The pedigree below was obtained for a rare kidney disease.a. Deduce the inheritance of this condition, stating your reasons. b. If persons 1 and 2 marry, what is the probability that their first child will have the kidney disease?In the 1800s, a man with dwarfism who lived in Utah produced a large number of descendants: 22 children, 49 grandchildren, and 250 greatgrandchildren (see the illustration of a family pedigree to the right), many of whom also exhibited dwarfism (F. F. Stephens. 1943. Journal of Heredity 34:229–235). The type of dwarfism found in this family is called Schmid-type metaphyseal chondrodysplasia, although it was originally thought to be achondroplastic dwarfism. Among the families of this kindred, dwarfism appeared only in members who had one parent with dwarfism. When one parent exhibited dwarfism, the following numbers of children were produced. Q. Use chi-square tests to determine if the numbers of children with each phenotype in family C (1 with normal stature, 6 with dwarfism) and in family D (6 with normal stature, 2 with dwarfism) are significantlydifferent from the numbers expected on the basis of your proposed mode of inheritance. How would you explain these deviations from the…Victoria’s youngest child, Beatrice, gave birth to one daughter, one normal son, and two hemophilic sons. **Based on the pedigree, Alfonso XIII of Spain is phenotypically normal. Does that mean he received the normal gene from Beatrice? Why or Why not?**
- Take the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects people from around the Mediterranean. This disease is associated with an anomaly of hemoglobin, a protein essential for the transport of oxygen, which is composed of four chains: two alpha (a) and two beta (B). In case of B-thalassemia, the ẞ chains are produced in insufficient or no quantity in an individual homozygous recessive resulting in insufficient production of overall hemoglobin leading to anemia and other physiological challenges. The gene that controls the synthesis of the ẞ chains is located on chromosome 11. Here is part of the coding portion of this gene (which controls a total of 146 amino acids and of which you only see the portion 36 to 41) and one of the targeted mutations: 1. Give the sequence of amino acids from the template and mutated strands. 2. What type of point mutation is it? 3. Using the principles of the theory of evolution, explain briefly and generally why…Using the provided image. Using only the pattern in the pedigree what mode of heredity would you predict hemophilia to follow? Provide an explanation for why you choose that mode:The pedigree below is a sex-linked disorder. Given the pedigree below, which characteristic is described? Explain by writing out the genotypes of all individuals.
- Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor anemia or a major anemia. Assuming that only a single gene pair and two alleles are involved in the inheritance of these conditions, is thalassemia a dominant or recessive disorder?Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. If they have a normal child, what is the probability that he or she will be heterozygous? Show solutions.Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. 1. Give the genotypes of Jillian and Jacob. Assuming that they will have 4 children, what is the probability that: 2. all their children will be normal? 3. they will have a son with Huntington’s disease? 4. they will have a daughter inflicted with both conditions