Extraction (Part 2) Experiment: Separation of Neutral and basic Substances NH2 Handle aromatic amines with care. Most are toxic and some are carcinogenic. Avoid breathing the dust and vapor from the solid and keep the compounds off the skin, best done by wearing gloves. Naphthalene mp 80°C 4-Chloroaniline mp 68–71°C, pK, 10.0 1) Dissolve 2g of mixture in 20 mL of ethyl ether, and transfer the mixture to a 125 mL separatory funnel. 2) Add 10 mL of H,O and 10 mL of a 3M HCl solution into the funnel. 3) Stopper the funnel, shakes the mixture thoroughly with frequent venting of the funnel. 4) Allow the layers to separate completely, then draw off the lower layer into a 50 mL flask (flask 1) 5) Repeat the process with another 10 mL of HCl. Draw off the lower layer into flask 1. Correct positions for holding a separatory funnel when shaking. FIG. 3

Extraction (Part 2) Experiment: Separation of Neutral and basic Substances NH2 Handle aromatic amines with care. Most are toxic and some are carcinogenic. Avoid breathing the dust and vapor from the solid and keep the compounds off the skin, best done by wearing gloves. Naphthalene mp 80°C 4-Chloroaniline mp 68–71°C, pK, 10.0 1) Dissolve 2g of mixture in 20 mL of ethyl ether, and transfer the mixture to a 125 mL separatory funnel. 2) Add 10 mL of H,O and 10 mL of a 3M HCl solution into the funnel. 3) Stopper the funnel, shakes the mixture thoroughly with frequent venting of the funnel. 4) Allow the layers to separate completely, then draw off the lower layer into a 50 mL flask (flask 1) 5) Repeat the process with another 10 mL of HCl. Draw off the lower layer into flask 1. Correct positions for holding a separatory funnel when shaking. FIG. 3

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter16: Aldehydes And Ketones

Section: Chapter Questions

Problem 16.39P

See similar textbooks

Similar questions

Does it safe to use this sunscreen K on acne prone skin. And can we rinse off it by only using facial gel mixed with water to rinse off it without use oil. Do I need to use micellar water for removing cosmetic before rinse off it with facial gel Sunscreen K has lists of ingredients below (descending order)…. AQUA DIMETHICONE CYCLOPENTASILOXANE PROPYLENE GLYCOL NIACINAMIDE DIETHYLHEXYL CARBONATE ZINC OXIDE CETEARYL ALCOHOL POLYMETHYL METHACRYLATE SODIUM POLYACRYLOYL-DIMETHYL TAURATE TITANIUM DIOXIDE ETHYLHEXYL METHOXYCINNAMATE BUTYL METHOXYDIBENZOYLMETHANE GLYCERYL STEARATE BIS-PEG/PPG-20/5 PEG/PPG-20/5 DIMETHICONE METHOXY PEG/PPG-25/4 DIMETHICONE HYDROGENATED POLYDECENE BUTYLENE GLYCOL OCTOCRYLENE PEG-40 STEARATE PHENOXYETHANOL HEXYL LAURATE POLYHYDROXYSTEARIC ACID CAPRYLIC/CAPRIC TRIGLYCERIDE STEARIC ACID CETYL ALCOHOL PEG-10 DIMETHICONE CETEARETH-20 TOCOPHERYL ACETATE STEARYL ALCOHOl PHENYL TRIMETHICONE TRIETHOXYCAPRYLYSILANE TRIDECETH-10 CHLORPHENESIN DISODIUM EDTA DIMETHICONOL…
Propose you are given a mixture of naphthalene, propanoic acid, and diethyl amine. Explain, using a flow chart similar to that in #1, how you would separate these three compounds. Include all solvents and reagents, show the exact compound that is present at each juncture, and be clear about the experimental technique employed in each step.
use your knowledge of acid-base extraction to come up with a plan to separate the following compounds from each other. Your plan should include specific solvents or reagents to be used and result in 4 isolated solids in the end. p-anisidine pyrene salicylic acid: 2,3-xylenol *Here is an hint and example: p=Anisidine is an amine, xylenol is a phenol, and salicylic acid has COOH and phenol groups. Always start with identifying the functional groups and you either add acids or bases to react then after you get your layer, you extract and normally you will get precipitation at the bottom and you collect it by vacuum iteration, solate the amine by extracting with HCl. The ammonium salt will be in the aqueous layer. Neutralize it by adding base (NaOH) until the solution is basic. Collect the amine(which we expect to precipitate) by vacuum filtration.
Write the reactions of Aromatic Primary - aliphatic secondary and tertiary amines with 2 N HCl and 5% NaNO2 in ice bath at 50C
You have learned that ester may be hydrolyzed in aqueous base. Why does a workup using 50ml of 10% NaOH and 50g of ice not hydrolyze a nitro benzocaine derivative?
Q1. Discuss the role of the following reagents in the extraction of caffeine. a. Vinegarb. Baking soda Q2. What are emulsions? Why do they form during extractions? How is their formation minimized? Q3. Why is it necessary to turn the separatory funnel upside down and to open thestopcock?
1. outline a procedure for separating a mixture of naphthalene (a neutral compound), toluic acid (an acidic compound), and p-bromoaniline (a basic compound). Assume that toluic acid and p-bromoaniline are completely insoluble in water. 2. The solubility of Lorazepam (a tranquilizer found in Emotival , Lorax, Wypax, and other prescription medicines) is 0.08mg/mL and 2.62mg/mL, in water and chloroform, respectively. Estimate the partition coefficient of lorazepam between chloroform and water. 3. The solubility of benzoic acid at 25 degrees Celsius in water and diethyl ether is 3.35 mg/mL and 0.353 g/mL, respectively. Estimate the percent recovery of benzoic acid in the organic phase, if a solution of benzoic acid in water is extracted with an equivalent volume of ether. [HINT-pay attention to the units] 4. The solubilities of cholesterol in water and chloroform are 0.550mg/100mL and 1.00g/5.25mL, respectively. Estimate the partition coefficient of cholesterol between chloroform and…
1. Write the observations and results when (a)Fumaric Acid is reacted with Sodium Hydroxide,(b)when reacted with Sodium Bicarbonate. Write also the reaction equations. 2. Solubility of Amines in AcidPut 2 ml of water in a 10x75-mm test tube. Add 5 to 10 drops of aniline. Add 6 N hydrochloric acid dropwise until the aniline dissolves. Then add 6 N sodium hydroxide until the aniline reappears. Write the observations/results in this experiment and the reaction equation.
Show how you would use extractions with a separatory funnel to separate a mixture of the following compounds: benzoicacid, phenol, benzyl alcohol, aniline
Please help The petition coeficiente between benzene and water for carta iLife is approximately 3.9 .you are given a 0.35 g sample of acetanilide dissolved in 100ml of water Which of the following extraction techniques will give q better recovery of.acetanilide from water A) one extraction with 60ml of benzene or b) two successive extractions with 30ml portions of benzene? Show calculation
A student was trying to determine the identity of an unknown compound. The melting point of the compound was 117-118oC. The student narrowed the possible compound down to the following: Compound Melting Point Range acetanilide 113-115oC fluorene 114-116oC mandelic acid 120-122oC A second student, doing the same experiment as above, found that their melting point was 100-108oC. What is wrong with the student’s melting point? Propose two reasons why the melting point could be incorrect. View keyboard shortcuts
If the reaction mixture containing p-aminophenol, distilled H2O, and acetic anhydride was heated to 200 degrees celsius what would have happened? (Originally, was heated to 95-100 degrees celsius and formed crude Acetaminophen for my Acetaminophen lab, but am unsure if heated at 200) Please help! Thanks in advance!!!