Gene silencing is mediated by a number of short (~20 nt) noncoding RNAs known as what? - These noncoding RNAs bind to a protein family that uses single-stranded small nucleic acids as guides to complementary sequences in RNA or DNA for silencing. What protein family is this? - This RNA-Protein complex attached to DNA forms an overall complex called what? - The RNA described above doesn’t start out in that form. It is first transcribed in the nucleus as a primary transcript. Describe how this primary transcript is processed and indicate the important proteins in the processing scheme.
Small nucleolar RNAs (snoRNAs) form a large abundant family of noncoding RNAs predominantly localized
in the nucleolus. Based on conserved sequence motifs, snoRNAs fall into one of two classes—box C/D
snoRNAs or box H/ACA snoRNAs. Each snoRNA associates with a set of class-specific and well-characterized
core proteins to form ribonucleoprotein (RNP) complexes referred to as small nucleolar ribonucleoproteins, i.e.,
box C/D snoRNPs and box H/ACA snoRNPs.
- Gene silencing is mediated by a number of short (~20 nt) noncoding RNAs known as what?
- These noncoding RNAs bind to a protein family that uses single-stranded small
guides to complementary sequences in RNA or DNA for silencing. What protein family is this?
- This RNA-Protein complex attached to DNA forms an overall complex called what?
- The RNA described above doesn’t start out in that form. It is first transcribed in the nucleus as a primary
transcript. Describe how this primary transcript is processed and indicate the important proteins in the
processing scheme.
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