Here I have numbèred the atoms in the imidazole ring for you. Notice that the N at position #4 at the top of the ring does not have a lone pair outside the ring. To satisfy Huckel's Rule, that lone pair has to be inside the ring, meaning it would not be available for hydrogen bonding. histidine NH NH2 serine но- но. 3 INH2 active site 2 H- regenerated R. If the imidazole ring were rotated 180 degrecs, so that #4 is down and # 2 is up, then the hydrogen bond with the H on the serine hydroxyl group would not happen. But a hydrogen bond between the O of serinc and the H on N # 4 could happen. There must be something else keeping the imidazole ring oriented as shown. The P domain is arranged so that there is an aspartate side chain just above the imidazole ring. What is the charge of the aspartate side chain at physiologic pH? (Please look up the pKa on the internet) +1 O neutral

Here I have numbèred the atoms in the imidazole ring for you. Notice that the N at position #4 at the top of the ring does not have a lone pair outside the ring. To satisfy Huckel's Rule, that lone pair has to be inside the ring, meaning it would not be available for hydrogen bonding. histidine NH NH2 serine но- но. 3 INH2 active site 2 H- regenerated R. If the imidazole ring were rotated 180 degrecs, so that #4 is down and # 2 is up, then the hydrogen bond with the H on the serine hydroxyl group would not happen. But a hydrogen bond between the O of serinc and the H on N # 4 could happen. There must be something else keeping the imidazole ring oriented as shown. The P domain is arranged so that there is an aspartate side chain just above the imidazole ring. What is the charge of the aspartate side chain at physiologic pH? (Please look up the pKa on the internet) +1 O neutral

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.21P

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