Which of the following statements concerning uncompetitive inhibitors is NOT true? a. They decrease the Km O b. They bind to both ES and Enzyme O c. They decrease the Vmax Od. They bind to ES only O e. No product is formed after their binding
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- The same enzyme as studied in the presence of a different inhibitor (inhibitor B). In this case, two different concentrations of inhibitor are used. Data are as follows: (a) What kind of inhibitor is inhibitor B?(b) Determine the apparent Vmax and KM at each inhibitor concentration.(c) Estimate K1 from these data.A drug with which of the following molecular mechanisms of action would be least likely to function as a DHFR inhibitor? Group of answer choices A) Block substrate from binding to the DHFR active site B) Alter folding to increase NADPH cofactor binding C) Increase DHFR degradationWhich statement is true about noncompetitive inhibition? a. Binding of the inhibitor occurs to the active site of the enzyme b. Inhibition is irreversible c. Increasing the amount of substrate does not reverse the inhibition d. We talked about it in context of aspirin inhibiting blood clotting
- An inhibitor that reversibly binds to a site other than the enzyme's active site is called a(n) a. noncompetitive inhibitor b. competitive inhibitor c. antagonisitc inhibitor d. antibioticAssuming an excess of substrate, if the enzyme concentration is doubled in a reaction vessel, the number of substrate molecules converted to product per minute will: a. be 1/2 as much as originally b. remain the same as originally c. be twice as much as originally d. only be able to be determined experimentally e. no correct response is givenThe enzyme trypsin is sold as a dietary enzyme supplement. Explain what happens to trypsin taken with food.
- Which of the following statements about non-competitive inhibitors is true? A) They bind at the active site of the enzyme and block access to the substrate. B) They bind at a location away from the active site. C) They function by changing the shape of the enzyme's active site. D) B and CWhich of the following types of drugs will have maximum oral bioavailability?A. Drugs with high first-pass metabolism.B. Highly hydrophilic drugs.C. Largely hydrophobic, yet soluble in aqueous solutions.D. Chemically unstable drugs.E. Drugs that are P-glycoprotein substrates.A drug with which of the following molecular mechanisms of action would be least likely to function as a DHFR inhibitor? a.Increase DHFR degradation b.Block substrate from binding to the DHFR active site c.Alter folding to increase NADPH cofactor binding
- Which of the following is incorrect regarding the active site of anenzyme?a. is unique to that enzymeb. is the part of the enzyme where its substrate can fitc. can be used over and over againd. is not affected by environmental factors, such as pH andtemperatureβ-lactamase production by bacteria is an example of which of the following types of resistance? a. change in the permeability of the drug b. None of the above c. overproduction of an enzyme in a key metabolic pathway d. removal of the drug via a pump e. alteration of the target of the drugAn enzyme-substrate solution has been "poisoned" with a noncompetitive inhibitor. It is expected that the addition of more substrate to the solution will _____ the activity of the enzyme. a. increase b. decrease c. have no effect on
