HN. Bupropion 8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include calculations showing the percentage of the drug which is ionised.

HN. Bupropion 8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include calculations showing the percentage of the drug which is ionised.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter20: Acidity And Pka Of Phenols

Section: Chapter Questions

Problem 3CTQ

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Concept explainers

Ionic Equilibrium

Chemical equilibrium and ionic equilibrium are two major concepts in chemistry. Ionic equilibrium deals with the equilibrium involved in an ionization process while chemical equilibrium deals with the equilibrium during a chemical change. Ionic equilibrium is established between the ions and unionized species in a system. Understanding the concept of ionic equilibrium is very important to answer the questions related to certain chemical reactions in chemistry.

Arrhenius Acid

Arrhenius acid act as a good electrolyte as it dissociates to its respective ions in the aqueous solutions. Keeping it similar to the general acid properties, Arrhenius acid also neutralizes bases and turns litmus paper into red.

Bronsted Lowry Base In Inorganic Chemistry

Bronsted-Lowry base in inorganic chemistry is any chemical substance that can accept a proton from the other chemical substance it is reacting with.

Question

Please answer all questions and subparts aligned with our honor code.

HN.
Bupropion
8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent
tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include
calculations showing the percentage of the drug which is ionised.
9) A 1.0 L buffer solution is prepared and has a final concentration of 0.6 M ammonium chloride and
0.40 M ammonia. The pKa of ammonium chloride is 9.12.
a) Calculate the pH of the buffer solution.
b) If 100 ml of a 1M HCl solution was added calculate the new pH.

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