How can alteration in chromosome number or structure impact living organism? Explain how Down's syndrome, Turner's Syndrome or Kleinfelter syndrome can occur? How could meiosis prodcue a gamete with 2 copies of a homologous chromosome, instead of 1 copy?

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How can alteration in chromosome number or structure impact living organism? Explain how Down's syndrome, Turner's Syndrome or Kleinfelter syndrome can occur? How could meiosis prodcue a gamete with 2 copies of a homologous chromosome, instead of 1 copy? 

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