Asked Oct 17, 2019

How do bacteria ensure the start codon of the mRNA is positioned properly during translation initiation?


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Step 1

The translation is defined as the process that generates a new polypeptide from mRNA with the help of ribosomes. The translation process is divided into four main steps: activation, initiation, elongation, and termination. The process of translation requires translation factors that are different in prokaryotes and eukaryotes.

Step 2

The initiation of translation requires the recruitment of components of the translation system. These components are tRNA molecule, GTP as an energy source, initiation factors (IF1, 1F2, 1F3), mRNA molecule and two ribosomal subunits (the 30S and 50 S).

The positioning of the initiation complex is important. An interaction between a smaller subunit of ribosome (30 S) and mRNA transcript determines the translation site. Commonly AUG is the start codon in prokaryotes. ...

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Molecular Biology

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