Answered: How Quinapril (trade name Accupril) is…

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Chemistry

How Quinapril (trade name Accupril) is made & why it is used?

Macroscale and Microscale Organic Experiments

7th Edition

ISBN:9781305577190

Author:Kenneth L. Williamson, Katherine M. Masters

Publisher:Kenneth L. Williamson, Katherine M. Masters

Chapter7: Extraction

Section: Chapter Questions

Problem 9Q

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Concept explainers

Analyzing and Predicting Spectroscopic Data

The interaction of electromagnetic radiation with the structure of molecules in the sample and their study is referred spectroscopy. Several spectroscopic methods are used to acquire sample information, and these methods are proved to be accurate, fast, and non-destructive. The information obtained about the content and composition of molecules from these spectroscopic methods is called spectroscopic data.

Question

How Quinapril (trade name Accupril) is made & why it is used?

Expert Solution

Step 1

Quinapril is a prodrug which is also called as Accupril. It is a non-sulfhydryl angiotensin converting enzyme inhibitor with antihypertensive activity

Step 2

The synthesis of Quinapril involves the reaction of alkyl bromide with an amino ester. The product formed undergo condensation to form quinapril. The preparation is as follows:

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Analyzing and Predicting Spectroscopic Data

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