Please advise on the below for a punnet sqaure Brian is 15 months old. He has recently been diagnosed with X-linked ichthyosis. He is in the clinic with his family to receive the results of the genetic testing. The testing has been done to find out if Brian has an inherited or sporadic form of the disorder. Faisal and Nadia, Brian’s parents, are worried because they are expecting their second child, another boy, in about 3 months. Nadia’s medical notes reveal that she experienced significant post-natal depression after Brian’s birth. The clinician informs them that Nadia is a carrier of a causative mutation and asks them for a family history. Nadia explains that she has an older sister and that her mother miscarried a baby at about 16 weeks before going on to conceive Nadia. Nadia’s sister is married and has one healthy daughter aged 6. Nadia and her sister lost contact with their mother after she left their dad, but they are still in touch with their maternal grandmother, Lily, who has an identical twin, Hannah. Lily and Hannah both married young and each had two children. Hannah had a girl, then a boy and Lily had a boy, then a girl. Nadia tells you that Lily’s son, Leo (Nadia’s maternal uncle) died very young but that she doesn’t know what of because Lily did not like to speak of it. Nadia tells you that her grand-maternal Aunt Hannah’s youngest child, Eman, has Down Syndrome. He lives quiet and independent life in supported housing. Eman’s older sister, Pearl, didn’t marry but had two daughters by two different fathers. The first daughter has twins (runs in the family). Nadia sees the younger daughter, Asma, quite often; they are going to anti-natal classes together. Asma has one son who is aged 7 and is expecting another boy about a month after Brian’s brother is born. The clinician asks if Nadia would be willing to disclose her genetic status to her wider family. She says that she is willing. Then the clinician asks if Nadia will supply contact details for Lily, Asma and Jo, to enable the hospital to contact them and ask them to consider genetic testing for the X-linked ichthyosis causing mutation. Nadia agrees. She doesn’t have details for Jo, but she will ask Asma. The clinician explains that Asma’s older sister should be informed too and anyone else who might be a carrier. Nadia is unable to say whether her mother has had more children. Faisal informs you that he is red-green colour-blind and asks if that matters.
Please advise on the below for a punnet sqaure
Brian is 15 months old. He has recently been diagnosed with X-linked ichthyosis. He is in the clinic with his family to receive the results of the genetic testing. The testing has been done to find out if Brian has an inherited or sporadic form of the disorder. Faisal and Nadia, Brian’s parents, are worried because they are expecting their second child, another boy, in about 3 months. Nadia’s medical notes reveal that she experienced significant post-natal depression after Brian’s birth. The clinician informs them that Nadia is a carrier of a causative mutation and asks them for a family history.
Nadia explains that she has an older sister and that her mother miscarried a baby at about 16 weeks before going on to conceive Nadia. Nadia’s sister is married and has one healthy daughter aged 6. Nadia and her sister lost contact with their mother after she left their dad, but they are still in touch with their maternal grandmother, Lily, who has an identical twin, Hannah. Lily and Hannah both married young and each had two children. Hannah had a girl, then a boy and Lily had a boy, then a girl. Nadia tells you that Lily’s son, Leo (Nadia’s maternal uncle) died very young but that she doesn’t know what of because Lily did not like to speak of it. Nadia tells you that her grand-maternal Aunt Hannah’s youngest child, Eman, has Down Syndrome. He lives quiet and independent life in supported housing. Eman’s older sister, Pearl, didn’t marry but had two daughters by two different fathers. The first daughter has twins (runs in the family). Nadia sees the younger daughter, Asma, quite often; they are going to anti-natal classes together. Asma has one son who is aged 7 and is expecting another boy about a month after Brian’s brother is born.
The clinician asks if Nadia would be willing to disclose her genetic status to her wider family. She says that she is willing. Then the clinician asks if Nadia will supply contact details for Lily, Asma and Jo, to enable the hospital to contact them and ask them to consider genetic testing for the X-linked ichthyosis causing mutation. Nadia agrees. She doesn’t have details for Jo, but she will ask Asma. The clinician explains that Asma’s older sister should be informed too and anyone else who might be a carrier. Nadia is unable to say whether her mother has had more children.
Faisal informs you that he is red-green colour-blind and asks if that matters.
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