How would the addition of a protein kinase A inhibitor affect the response of an adipocyte to glucagon? A.A protein kinase A inhibitor would block glucagon from binding to its receptor. B. A protein kinase A inhibitor would increase the cell's response to glucagon, enhancing fatty acid mobilization. C.A protein kinase A inhibitor would not affect the cell's response to glucagon. D.A protein kinase A inhibitor would decrease the cell's response to glucagon, weakening the signal for fatty acid mobilization.

Protein kinase A (PKA) also known as cyclic adenosine monophosphate (cAMP) dependent protein kinase.…

Answered: How would the addition of a protein…

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter17: Anti-infective Drugs

Section: Chapter Questions

Problem 20CRQ

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. Which observation suggested to Sutherland the involvementof a second messenger in epinephrine’s effect on liver cells?(A) Enzymatic activity was proportional to the amount ofcalcium added to a cell-free extract.(B) Receptor studies indicated that epinephrine was a ligand.(C) Glycogen breakdown was observed only when epinephrinewas administered to intact cells.(D) Glycogen breakdown was observed only when epinephrineand glycogen phosphorylase were mixed.
A hormone signals through a G protein-coupled receptor as shown in the diagram. After the production of IP3, which of these events will MOST quickly stop the transduction of the signal? A. the hydrolysis of IP3 B. the hydrolysis of GTP C. the hydrolysis of PIP2 D. the hydrolysis of the hormone I believe the answer is (B) the hydrolysisof GTP, because the G protein becomes inactive after GTP is hydrolyzed to GDP. However, the solution provided by Bartleby is (C). Please explain. Thanks
(a) Predict the effect of a mutation that enhances the activity of the kinase associated with the PDH complex. (b) Predict the effect of a mutation that reduces the activity of the phosphatase associated with the PDH complex.
Which of the following enzymes does NOT catalyzes the formation a second messenger? A. PI3K B. Protein kinase C C. Phospholipase C D. Guanylyl cyclase Which of the following statements is correct? A. Lipolysis is inhibited by epinephrine and glucagon B. Phosphorylation of triacylglycerol lipase inhibits its activity C. Activation of protein kinase A inhibits lipolysis D. Fatty acids are activated in mitochondria before undergoing b-oxidation E. Lipolysis is stimulated by cAMP F. None of the above
You find a monster that produces a hormone that uses standard G-protein receptor pathways to prepare the creature for lunch. Outline two signaling pathways used by the hormone when binding to a receptor, and indicate how you might modify the monsters cells so it doesn’t eat you. (how would you block each of the pathways by blocking production of a component?).
Given what we know about epinephrine and glucose 6-phosphate dehydrogenase, would you predict that glucose 6-dehydrogenase is activated, inhibited, or unaffected by epinephrine induced cell signaling? Explain your prediction.
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Using the cAMP signalling pathway as an example, describe the ways in which signalling can be switched on or off at different levels in the pathway . Give examples of two drugs that can affect switching in the pathway, indicating their mechanism of action. Use diagrams to illustrate your answer
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in the insulin signaling pathway, the function of the PIP3-dependent Protein Kinase-1 is to add a __ group to the enzyme __ , which activates that enzyme.
The hormone glucagon binding to its receptor induces a signaling cascade that ends with phosphorylation of the enzyme phosphofructokinase-2 by protein kinase A in the liver. Describe how binding of glucagon to its receptor likely leads to phosphorylation of phosphofructokinase-2.

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	A.	A protein kinase A inhibitor would block glucagon from binding to its receptor.
	B.	A protein kinase A inhibitor would increase the cell's response to glucagon, enhancing fatty acid mobilization.
	C.	A protein kinase A inhibitor would not affect the cell's response to glucagon.
	D.	A protein kinase A inhibitor would decrease the cell's response to glucagon, weakening the signal for fatty acid mobilization.