Hox genes regulate the identity of serially repeated structures in vertebrates (a) Wild type (b) Ноха11*/Ноха11%; (c) Hoxa11-IHoxa11; Hoxd11IHoxd11 Haxd11IHaxd11 FIGURE 13-11 The morphologies of different regions of the vertebral column are regulated by Hox genes. (a) In the mouse, six lumbar vertebrae form just anterior to the sacral vertebrae (numbers in red). (b) In mice lacking the function of the posteriorly acting Hoxd11 gene and possessing one functional copy of the Hoxa11 gene, seven lumbar vertebrae form and one sacral vertebra is lost. (c) In mice lacking both Hoxa11 and Hoxd11 function, eight lumbar vertebrae form and two sacral vertebrae are lost. [Photographs courtesy of Dr. Anne Boulet, HHMI, University of Utah; from S. B. Carroll, J. K. Grenier, and S. D. Weatherbee, From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, 2nd ed. Blackwel, 2005.)

Hox genes regulate the identity of serially repeated structures in vertebrates (a) Wild type (b) Ноха11*/Ноха11%; (c) Hoxa11-IHoxa11; Hoxd11IHoxd11 Haxd11IHaxd11 FIGURE 13-11 The morphologies of different regions of the vertebral column are regulated by Hox genes. (a) In the mouse, six lumbar vertebrae form just anterior to the sacral vertebrae (numbers in red). (b) In mice lacking the function of the posteriorly acting Hoxd11 gene and possessing one functional copy of the Hoxa11 gene, seven lumbar vertebrae form and one sacral vertebra is lost. (c) In mice lacking both Hoxa11 and Hoxd11 function, eight lumbar vertebrae form and two sacral vertebrae are lost. [Photographs courtesy of Dr. Anne Boulet, HHMI, University of Utah; from S. B. Carroll, J. K. Grenier, and S. D. Weatherbee, From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, 2nd ed. Blackwel, 2005.)

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter50: Animal Development

Section: Chapter Questions

Problem 14TYK

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