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- Which of the following are mechanisms by which cancer drugs work (select all that apply)? A. Inhibit activity of oncogene B. Promote apoptosis C. Promote terminal differentiation of cells D. Inhibit drug transporters E. Promote DNA damage.name any two methods that can possibly cure cancer .In your own words, explain each of the hallmarks of cancer. (immortality, produce go signals, override stop signals, resist cell death, angiogenesis and how it relates to metastasis.
- What are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single tumor-suppressor gene.c. the activation of multiple oncogenes.d. the activation of multiple oncogenes and the inactivation ofmultiple tumor-suppressor genes.What is meant by targeted cancer therapies, and what advantages do they offer?
- Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the phenotype of cancer (stem?) cells.Out of these 8 hallmarks ( sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, deregulating cellular energetics and metabolism, and avoiding immune destruction). Rank them from least important to most for cancer development. Explain in 2-3 sentences how.Which of the following statements are correct about inflammation and cancer (select all that apply)? A. Inflammatory cells are often detected in tumor samples B. The inflammatory cytokine TNF has been shown to have direct transforming properties C. Cancer often arises at sites of chronic inflammation D. Use of NSAIDs has been associated with increased mortality from colorectal cancer E. Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis
