In an ethnic population, there is a constant prevalence of familial hypercholesterolemia with frequency of 1 in 4000 individuals having a severe form and 1 in 32 a mild form. Familial hypercholesterolemia is a genetic disease with an incomplete dominant inheritance pattern in which the severe cases are homozygous mutant and the mild cases are heterozygous. Based on this information: (i.) Is the population in the Hardy- Weinberg equilibrium? (ii.) Taking this into consideration, what is the closet estimate f the chance that a newly born baby (in the next generation) will not develop any form of

In an ethnic population, there is a constant prevalence of familial hypercholesterolemia with frequency of 1 in 4000 individuals having a severe form and 1 in 32 a mild form. Familial hypercholesterolemia is a genetic disease with an incomplete dominant inheritance pattern in which the severe cases are homozygous mutant and the mild cases are heterozygous. Based on this information: (i.) Is the population in the Hardy- Weinberg equilibrium? (ii.) Taking this into consideration, what is the closet estimate f the chance that a newly born baby (in the next generation) will not develop any form of

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter18: Genetics Of Behavior

Section: Chapter Questions

Problem 14QP: A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known...

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If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known clinically relevant allele is 1/8500 in a given population, what is the frequency of the wild type allele? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.
a. Alleles of genes on the X chromosome can also be atequilibrium, but the equilibrium frequencies underthe Hardy-Weinberg assumptions must be calculatedseparately for the two sexes. For a gene with two alleles A and a at frequencies of p and q, respectively,write expressions that describe the equilibrium frequencies for all the genotypes in men and women.b. Approximately 1 in 10,000 males in the UnitedStates is afflicted with hemophilia, an X-linkedrecessive condition. If you assume that the population is at Hardy-Weinberg equilibrium, what proportion of American females would be hemophiliacs?About how many female hemophiliacs would youexpect to find among the 170 million women livingin the United States? (Assume that all females withhemophilia are homozygous for the disease allele.)
Consider the case of a hypothetical genetic disease called WhySciEleven (WSE), an inherited disease that results to the inability to complete production of an amino acid “moduleactivity” that results in brain damage if untreated. WSE is due to a recessive allele. Given one WSE occurrence per 10,000 births. Which term in the Hardy-Weinberg equation corresponds to the frequency of individuals who have no alleles for the disease WSE? a. p b. 2pq c. p2 d. q2
If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/9250 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.
Tay-Sachs disease is caused by loss-of-function mutations in a gene on chromosome 15 thatencodes a lysosomal enzyme. Tach-Sachs is inherited as a autosomal recessive conidition.Among Ashkenazi Jews of central European ancestry, about 1 in 3600 children is born withthe disease. What fraction of the individuals in this population are carriers? (Assume thepopulation is in Hardy-Weinberg equilibrium)
If 83% of the Elmo Muppet population has a condition that makes them refer to themselves in the third person, and you know that this condition is the result of the homozygous recessive genotype (ee)… Assuming Hardy-Weinberg equilibrium, what is the allelic frequency of the dominant allele (E)? ______ Assuming Hardy-Weinberg equilibrium, what percent of the phenotypically normal population of are carriers of the recessive allele? ________ (NOTE this is asking for # that carry the allele/total "normal" population) In your answer, clearly answer with a number for both 1) and 2). Show calculations.
The ability to taste the compound PTC is controlled by a dominant allele T, while individuals homozygous for the recessive allele (t) cannot taste PTC. In a population consisting of 500 individuals, 347 are tasters and 153 are non-PTC tasters. Calculate the frequency of the T and t alleles in this population, and frequency of the genotypes. (Please train yourself to use the Hardy-Weinberg equation.) To present your answers, follow the format in the picture below.
The frequency of children homozygous for the recessive allele for the genetic disease cystic fibrosis is about one in 2,500. Assuming the population is in Hardy-Weinberg equilibrium, what is the expected frequency of heterozygotes (carriers) in the populat ion?
Identify each of the following as an example of allele, genotype,and/or phenotype frequency:A. Approximately 1 in 2500 individuals of Northern Europeandescent is born with cystic fibrosis.B. The percentage of carriers of the sickle cell allele in WestAfrica is approximately 13%.C. The number of new mutations per generation resultingin achondroplasia, a genetic disorder, is approximately5 × 10−5.
As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progeny
Using the HardyWeinberg Law in Human Genetics Suppose you are monitoring the allelic and genotypic frequencies of the MN blood group locus (see Question 2 for a description of the MN blood group) in a small human population. You find that for 1-year-old children, the genotypic frequencies are MM = 0.25, MN = 0.5, and NN = 0.25, whereas the genotypic frequencies for adults are MM = 0.3, MN = 0.4, and NN = 0.3. a. Compute the M and N allele frequencies for 1-year-olds and adults. b. Are the allele frequencies in equilibrium in this population? c. Are the genotypic frequencies in equilibrium?
Half of the worlds population eats rice at least twice a day. Much of this rice is grown in flooded conditions, and different strains of rice are tolerant (survive) or intolerant (die) under these conditions. Rice breeders used genetic crosses to test whether tolerance to flooding is a dominant trait. Researchers used three true-breeding flood-tolerant strains, FR143, BKNFR, and Kurk, and two true-breeding flood- intolerant strains, IR42 and NB, in the crosses. Results were obtained from three sets of crosses and are reported in the Table below: Results of cross of F1 to tolerant parent: F1 plants were crossed with the tolerant parent of the cross. Number of Plants Progeny Analyzed from Intolerant Tolerant Cross Alive Dead Total 1. F2 results of cross: IR42 FR13A 187 77 264 IR42 BKNFR 192 73 265 NB Kurk 142 52 195 2. Results of cross of F1 to intolerant parent: (F1 of IR42 FR13A) IR42 14 17 31 (F1 of IR42 BKNFR) IR42 15 10 25 (F1 of NB Kurk) NB 21 35 56 3. Results of cross of F1 to tolerant parent: (F1 of IR42 FR13A) FR13A 31 0 31 (F1 of IR42 BKNFR) BKNFR 28 0 28 (F1 of NB Kurk) Kurk 40 0 40 Do the data support the hypothesis that the tolerance trait is dominant? Justify your conclusion by explaining the results from each of the three sets of crosses in terms of genotypes and phenotypic ratios. Source: T. Setter et al. 1997. Physiology and genetics of submergence tolerance in rice. Annals of Botany 79:6777.