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Compare the bands of each set of parents to each of the babies and determine which baby belongs to which set of parents. Line up the bands and illustrate which bands each baby inherited from its mother and from its father.
Figure 1
DNA fingerprint data obtained from three sets of infants and three sets of
parents
(a) Identify which baby belongs to which set of parents.
(b) Explain why not all the bands in the mother’s or father’s profiles have a
counterpart in the baby’s DNA profile.
(c) List other examples where DNA fingerprinting could be used to identify an individual.
(d) Explain why blood typing may not be a viable method of determining which baby belongs to which parent.
(e) Identify the largest DNA fragment on the gel. Identify the smallest DNA
fragment on the gel.
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- Click on the link: https://www.dailymail.co.uk/news/article-4168946/Mum-world-s-black-woman-two-white-babies.html#ixzz4hvs1FUeM.Links to an external site. This case explores how skin color is inherited in humans, presented in the story of Catherine and Richard Howarth whose children are surprisingly light skinned compared to their Nigerian mother. Based on what you have learned about polygenic inheritance, explain how Richard and Catherine Howarth were able to produce light-skinned babies. Are the odds indeed 1 in a million? Include possible genotypes of the couple and their children to support your argument.Pedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?Does a pedigree drawn from the available information offer strong support for the idea that Noah was homozygous for the recessive trait albinism? What other information about later generations would you like to have?
- Produce a pedigree diagram to convey the information shown. Gill, has come along to the Genetic Clinic with her younger sister, Charlotte. They have been invited because Charlotte’s youngest child, Jamie, who is 10 months old, is experiencing multiple, recurring parallel infections. Jamie has two very healthy older siblings, the eldest is his sister, Penny, and the middle child is his brother, Charlie. Gill’s youngest child, her son, Tom, is only 18 months old but has been in constant contact with the hospital since he was born. He has had recurrent bouts of pneumonia, bronchitis, otitis, conjunctivitis, and sinusitis. He often has diarrhoea and, due to the incredible strain on his small body, he is failing to thrive. Thankfully his medical team were thorough in their investigations, and he has just been diagnosed with X-linked agammaglobulinemia. Tom has two older siblings, the youngest of whom, Ella, was conceived as a twin, though IVF, but her twin died in utero at about 9 weeks…Stefan has launched a paternity suit to determine whether he is the father of an orphan residing in a monastery. Can mitochondrial DNA be used to trace the paternity? Explain.In the human pedigree below, the filled symbols represent the affectedindividuals.Determine the mode of InheritanceDetermine the genotypes of the numbered individuals
- Explain, at the molecular level, why human genetic diseases oftenfollow a simple Mendelian pattern of inheritance, whereas mostnormal traits, such as the shape of your nose or the size of yourhead, are governed by multiple gene interactions.IN TRANSYLVANIA, SOME PEOPLE EXHIBIT TWO UNUSUAL TRAITS IN WHICH THEY HAVE VERY LONG FRONT TEETH AND THE INABILITY TO BE AWAKE WHEN THE SUN IS UP. BOTH OF THESE TRAITS APPEAR TO BE RECESSIVE. IF A WOMAN WHO IS HETEROZYGOUS FOR TEETH AND HOMOZYGOUS NORMAL FOR BEING IN THE SUN MARRIES A MAN WHO HAS BOTH THESE TRAITS, WHAT COULD BE THE PHENOTYPES AND GENOTYPES OF THEIR CHILDREN? USE A PUNNET SQUARE AND SHOW ALL WORK. LIST THE RATIOS FOR THE GENOTYPES AND PHENOTYPES.In pre-DNA fingerprint days, blood type was often used in paternity disputes to exclude possible fathers. If the man in question has type B blood, and the child has type A blood, and the mother has type AB blood, can the man be the father of the child? Group of answer choices Yes, but only if he is homozygous for the B allele No Yes, but only if he is heterozygous for the B allele Yes, but only if both of his parents were Type AB