If the imaginary replacement of either of two protons forms enantiomers, then those protons are said to be enantiotopic. The NMR is not a chiral probe, and it cannot distinguish between enantiotopic protons. They are seen to be “equivalent by NMR.” Show that the two Hc protons in cyclobutanol are enantiotopic.

EBK A SMALL SCALE APPROACH TO ORGANIC L
4th Edition
ISBN:9781305446021
Author:Lampman
Publisher:Lampman
Chapter61: Friedel–crafts Acylation
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If the imaginary replacement of either of two protons forms enantiomers, then those protons are said to be enantiotopic. The NMR is not a chiral probe, and it cannot distinguish between enantiotopic protons. They are seen to be “equivalent by NMR.” Show that the two Hc protons in cyclobutanol are enantiotopic.

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