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If X inactivation compensates for an extra X chromosome, why do Klinefeltermales (XXY) have problems with development?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 26QP: Fragile-X syndrome causes the most common form of inherited intellectual disability. What is the...

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If X inactivation compensates for an extra X chromosome, why do Klinefelter
males (XXY) have problems with development?

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X chromosome inactivation in a diploid XX female is not completely inactivated, explain?
Define the Random Monoallelic Expression: Inactivation of the X Chromosome ?
What is the spreading phase of X-chromosome inactivation? Whydo you think it is called a spreading phase?
Why does a single X chromosome cause infertility and other abnormalities in Turner Syndrome subjects?
Describe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.
Barr bodies are formed to adjust X chromosome dosage in species other than humans, such as Drosophila (fruit flies) and C. elegans (nematodes). True or False ?
Equalizing the Expression of X Chromosome Genes in Males and Females Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?
Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?
Fragile-X syndrome causes the most common form of inherited intellectual disability. What is the chromosomal abnormality associated with this disorder? What is the phenotype of this disorder?
The maternal-effect mutation bicoid (bcd) is recessive. Inthe absence of the bicoid protein product, embryogenesis isnot completed. Consider a cross between a female heterozygousfor the bicoid mutation (bcd+/ bcd-) and a homozygousmale(bcd-/ bcd-). How is it possible for a male homozygous for the mutationto exist?
Explain why a person with Klinefelter Syndrome (XXY) still exhibits abnormal phenotypes despite the fact that one of the extra X Chromosome is inactivated practically leaving an XY active sex chromosomes similar to a normal male?
What unusual feature of the Y chromosome allows some recombination among the genes found on it?