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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 7, Problem 19QP
Textbook Problem
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Equalizing the Expression of X Chromosome Genes in Males and Females

Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?

Summary Introduction

To determine: The reason due to which individuals with XXY genotype are sterile males despite one X being inactivated early in embryogenesis.

Introduction: Normal males carry XY chromosomes, whereas normal females carry XX chromosomes. The amount of the gene products expressed by the genes present on the X chromosome is equalized in both males and females through a process known as dosage compensation as one of the two X chromosomes present in the females is randomly inactivated when the embryo has around 32 cells.

Explanation of Solution

The males having XXY genotype are affected by Klinefelter syndrome because normal males have XY genotype.

The reason due to which individuals with XXY genotype are sterile males despite one X being inactivated early in embryogenesis is as follows:

  • There are certain regions called pseudoautosomal regions in X and the Y chromosomes and these regions are active despite the random inactivation of the X chromosomes...

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