II. While there are many different types of inhibitors, most have a very similar structure so they cancompete with the normal substrate (in this case dopamine). Of the molecules below, whichcompound do you think has the most promise as an inhibitor?HOa.a.#1Ca.a.#2N-HH₂POOHAlendronatea.a.#6NH₂-PO₂H₂CarbidopaUsing the same, amino acid orientation as you arrived at for Part I, show which inhibitor is mostpromisingCara.a.#5a.a.#3Raloxifenea.a.#4 I. Active site analysis.Below is a diagram of a putative active site for Monoamine oxidase. As we learned, the purpose oftertiary structure is to form a scaffold so you can orient just a few amino acids in the right orientationto promote binding and/or catalysis. The position where this occurs is the active site. The amino acidarchitecture of an active site is designed to bind substrates. Amino acid side chains are capable ofhydrogen bonding, ionic and hydrophobic interactions. Fill in each amino acid that you think issuitable for interacting with the part of the substrate it is closest to. Assume the pH will be at 7.0a.a.#1a.a.#2a.a.#6HOLondNH₂НОa.a.#5OHa.a.#3a.a.#4

Enzymes are high molecular weight protein that catalyse biochemical reactions. They contain a active…

II. While there are many different types of inhibitors, most have a very similar structure so they can compete with the normal substrate (in this case dopamine). Of the molecules below, which compound do you think has the most promise as an inhibitor? HO a.a.#1 N- H a.a.#2 H₂PO3 -PO₂H₂ OH Alendronate a.a.#6 NH₂ Carbidopa Using the same, amino acid orientation as you arrived at for Part I, show which inhibitor is most promising a.a.#5 Raloxifene a.a.#3 a.a.#4

II. While there are many different types of inhibitors, most have a very similar structure so they can compete with the normal substrate (in this case dopamine). Of the molecules below, which compound do you think has the most promise as an inhibitor? HO a.a.#1 N- H a.a.#2 H₂PO3 -PO₂H₂ OH Alendronate a.a.#6 NH₂ Carbidopa Using the same, amino acid orientation as you arrived at for Part I, show which inhibitor is most promising a.a.#5 Raloxifene a.a.#3 a.a.#4

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 23P: Using the ActiveModel for aldose reductase, describe the structure of the TIM barrel motif and the...

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