Impairment of intracellular calcium homeostasis in muscle fibers lead to chronic, severe muscle dysfunction. Impaired Calcium ATPase activity can lead to abnormal, persistent elevation of intracellular calcium concentrations. Explain how persistently high intracellular calcium concentration would affect cross-bridge formation, and muscle contractions, and muscle tension? (Mention the effects on the steps involved cross bridge formation, and muscle contraction/relaxation cycle, and overall muscle tension).

Impairment of intracellular calcium homeostasis in muscle fibers lead to chronic, severe muscle dysfunction. Impaired Calcium ATPase activity can lead to abnormal, persistent elevation of intracellular calcium concentrations. Explain how persistently high intracellular calcium concentration would affect cross-bridge formation, and muscle contractions, and muscle tension? (Mention the effects on the steps involved cross bridge formation, and muscle contraction/relaxation cycle, and overall muscle tension).

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter8: Muscle Physiology

Section: Chapter Questions

Problem 3RE

See similar textbooks

Similar questions

Explain why (a) calcium ions and (b) ACh are vital for muscle contraction.
Which region or organelle—cytosol, mitochondrion, or SR—contains the highest concentration of calcium ions in a resting muscle fiber? Which structure provides the ATP needed for muscle activity?
Describe the regulation of smooth muscle contraction by intracellular calcium and how cross-bridge cycling is terminated when calcium decreases again.
A skeletal muscle can be stimulated, under laboratory conditions, with a supramaximal stimulus. Is it possible for the muscle to respond with a supramaximal contraction? Explain
Where would you expect to find the greatest concentration of calcium in resting skeletal muscle ?
Recently, it has been observed that several muscle diseases and disorders are linked to problems with triad structure and function.One such disorder is called malignant hyperthermia, a dire hypermetabolic response to certain inhaled anesthetics such as halothane. Muscles become very rigid due to excessive contraction (especially the masseter muscle), the body temperature spikes, andmuscles break down. Death is certain if not treated. Given the principal symptoms of malignant hyperthermia, what is its likely cause?Propose a theoretical mechanism for a treatment that would dampen the deleterious effects of this disorder.
The filaments of skeletal muscle are moved by free energy derived from the hydrolysis of ATP. During sustained muscle contraction ATP levels remain fairly constant, while levels of creatine phosphate fall. Explain why this is so. Under what circumstances is an oxygen debt incurred during muscle contraction?
Describe the major events that occur when a muscle fiber contracts. Include all chemicals, structures and processes at a microscopic level starting at the neuromuscular junction and ending with the relaxation of the muscle fiber
Myofibis in muscle fibres are made up of repeating units of dark and light bonds called
What is the optimum muscle activity to undertake for muscular hypertrophy? Explain deeply.
one of the early symptoms of calcium deficiency is muscle cramps. explain why by outlining through a concise pathway of muscle contractions underlining the first step that is affected by calcium deficiency.
Briefly discuss the abundance of sarcoplasmic reticulum in skeletal muscle inrelation to its location.