In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 If the adults in the sampled cohort represent the parents of the next generation of offspring in the population, and assuming random mating among the adults to produce the children of the next generation, calculate the predicted genotype frequencies in the children of the next generation.

In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 If the adults in the sampled cohort represent the parents of the next generation of offspring in the population, and assuming random mating among the adults to produce the children of the next generation, calculate the predicted genotype frequencies in the children of the next generation.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 2QP: How Can We Measure Allele Frequencies in Populations? The MN blood group is a single-gene,...

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In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 Using the relative fitnesses w11 = 0.556, w12 = 0.667, w22 = 1, calculate the change in genotype frequencies from childhood to adulthood in the next generation, and calculate the mean fitness ϖ in the population in the next generation.
In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 If selection is acting on this locus, predict the genotype and allele frequencies of this locus when the population reaches equilibrium (no calculation necessary).
In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 a) If selection is acting on this locus, predict the genotype and allele frequencies of this locus when the population reaches equilibrium (no calculation necessary). b) If the adults in the sampled cohort represent the parents of the next generation of offspring in the population, and assuming random mating among the adults to produce the children of the next generation, calculate the predicted genotype frequencies in the children of the next generation. c) From the predicted genotype frequencies in (b), calculate the allele frequencies and the HWE expected…
In a longitudinal study, 100 children born on the same day were sampled in a population of interest, and genotyped at one locus that has two alleles, A1 and A2. The children were followed every seven years until adulthood. At the end of the study, 75 reproductive adults remained from the original cohort of 100 children. Genotype A1A1 A1A2 A2A2 Number of Children 48 36 16 Number of Adults 30 27 18 If selection is acting on this locus, what will be the mean fitness when the population reaches equilibrium?
In this fictitious example of a cohort study, we found that in a factory of 3,000 workers, 1,000 workers were exposed to toxic substances, and 2,000 were not. During the study period, 800 of the exposed workers developed some type of lung disease, and only 40 of the non-exposed workers developed a lung disease. A. What is the incidence of lung disease among exposed workers? Use 1,000 as the multiplication factor and answer should be in whole numbers. B. What is the incidence of lung disease among non-exposed workers? Use 1,000 as the multiplication factor and answer should be in whole numbers.
What would be the expected number of each genotype (round to the nearest whole number assuming genotype represents an individual) assuming the population was in Hardy Weinberg equilibrium? f(M1M1) = 0.127 f(M1M2) = 0.390 f(M2M2) = 0.300 f(M1M3) = 0.068 f(M2M3) = 0.105 f(M3M3) = 0.009 Referencing a p-value of 0.05 and a CV of 11.070, state if the population is in HWE. Genotype Observed Expected O–E (O–E)2 (O–E)2/E M1M1 M1M2 M2M2 M1M3 M2M3 M3M3 Chi-squared = Statement:
SNP microarray analysis shows the genotype at a particular locus for 984 people. 51 individuals are AA, 311 are AC and 622 are CC. Calculate genotype and allele frequencies. I Is this population in H-W Eq? Provide support using Chi Square analysis. State null hypothesis and whether you will reject or fail to reject the null hypothesis. Why is it NOT valid to show that p2 + 2pq + q2 =1 as evidence that population is in H-W Eq?
A hypothethical population of 10,000 humans has 6,840 individuals with the blood type AA, 2,860 individuals with blood type AB and 300 individuals with the blood type BB. What is the frequency of each genotype in this population? AA = AB = BB = What is the frequency of the A allele? What is the frequency of the B allele? If the next generation contained 25,000 individuals, how many individuals would have blood type BB, assuming the population is in Hardy-Weinberg equlibrium?
A POPULATION DATABASE CONTAINING 12345 ALLELES A PARTICULAR ALLELE X IS PRESENT FOR 458 TIMES. WHAT WOULD BE THE FREQUENCY OF GENOTYPE WHICH IS HOMOZYGOUS FOR THAT ALLELE?
Imagine, as early 20th century eugenicists did, a single locus at which there is a gene controllingstrength of mind. A2 is the allele for normalmindedness; A1 is the allele for feeblemindedness.A2 is dominant over A1. Imagine, as Henry H. Goddard (1914) did, that allele A1 = 0.1.• Using pencil and paper, what is the frequency of feebleminded individuals in thepopulation? (Use the Hardy-Weinberg equilibrium principle). If we had a population of1000 individuals, how many would be feebleminded? How many would be carriers forfeeblemindedness? How many would be homozygous normalminded?• If a eugenic sterilization law were universally enforced, such that all feeblemindedindividuals were sterilized before reaching sexual maturity, what would be the fitnessesof the three genotypes? Explain.• Using pencil and paper, what would be the frequency of allele A1 after a singlegeneration of eugenic sterilization. Use the numbers you calculated in part a, andassume that every nonsterilized individual…
In this fictitious example of a cohort study, we found that in a factory of 3,000 workers, 1,000 workers were exposed to toxic substances, and 2,000 were not. During the study period, 800 of the exposed workers developed some type of lung disease, and only 40 of the non-exposed workers developed a lung disease. C. What is the incidence of lung disease in exposed workers that can be attributed to being exposed to asbestos? Use the already rounded off answers in the previous items when computing and answer should be in whole numbers. D. What is the proportion of the total incidence of lung disease in those exposed workers that is attributable to asbestos? Use the already rounded off answers in the previous items when computing and answer should be in whole numbers.
Eugene Eisen selected for increased 12-day litter weight (total weightof a litter of offspring 12 days after birth) in a population of mice . The 12-day litter weight of thepopulation steadily increased, but then leveled off after about 17generations. At generation 17, Eisen took one family of mice from theselected population and reversed the selection procedure: in this group,he selected for decreased 12-day litter weight. This group immediatelyresponded to the reversed selection: the 12-day litter weight dropped 4.8g within 1 generation and dropped 7.3 g after 5 generations. On the basisof the results of the reverse selection, what is the most likely explanationfor the leveling off of 12-day litter weight in the original population?