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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
ISBN: 9781305251052
Textbook Problem

Using the Hardy–Weinberg Law in Human Genetics

Suppose you are monitoring the allelic and genotypic frequencies of the MN blood group locus (see Question 2 for a description of the MN blood group) in a small human population. You find that for 1-year-old children, the genotypic frequencies are MM = 0.25, MN = 0.5, and NN = 0.25, whereas the genotypic frequencies for adults are MM = 0.3, MN = 0.4, and NN = 0.3.

  1. a. Compute the M and N allele frequencies for 1-year-olds and adults.
  2. b. Are the allele frequencies in equilibrium in this population?
  3. c. Are the genotypic frequencies in equilibrium?

a.

Summary Introduction

To determine: The M and N allele frequencies for 1-year olds and adults.

Introduction: The allele frequency refers to number of times an allele occurs at a specific locus within a population. It can be represented as percentage or in fraction. The allele frequency is indicative of variation at a particular locus.

Explanation

The genotype frequency is denoted by q2. In case of children, the genotype frequencies are given as :

MM= (0.25)

NN= (0.25)

So in order to find the value of M and N allele separately then under root of q is taken.

Since,

q2= (0.25),

q = (0.5)

So in case of children the allele frequency of M allele is 0...

b.

Summary Introduction

To determine : Whether the allele frequencies are in equilibrium in the population or not.

Introduction: The allele frequency refers to number of times an allele occurs at a specific locus within a population. It can be represented as percentage or in fraction. The allele frequency is indicative of variation at a particular locus.

c.

Summary Introduction

To determine: Whether the genotype frequencies are in equilibrium in the population or not.

Introduction: Genotype can be described as the genetic constitution of an individual. Genotype constitutes of the genes which underlie the inheritance amongst organisms. Genotype frequency refers to the number of times a particular genotype occurs within a given population.

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