In comparison to experimental results from the genetic manipulation of an invertebrate model, what pathologic outcome(s) would suggest that multiple homologs of a disease gene are present in humans? a. Missing the essential gene homolog that is lethal in fruit flies is also lethal in human infants. b. Different homologs of the essential gene are each expressed in different human organs, and mutations in these duplicated genes cause organ-specific diseases. c. Different homologs of the essential gene are each expressed in different stages of early child development, and mutations in each of these duplicated genes cause different diseases. d. In humans, defects in different homologs of the essential gene cause different loss-of-function diseases due to subfunctionalization. e. The essential gene is lethal in fruit flies, but there is no disease phenotype exhibited in people.
In comparison to experimental results from the genetic manipulation of an invertebrate model, what pathologic outcome(s) would suggest that multiple homologs of a disease gene are present in humans? a. Missing the essential gene homolog that is lethal in fruit flies is also lethal in human infants. b. Different homologs of the essential gene are each expressed in different human organs, and mutations in these duplicated genes cause organ-specific diseases. c. Different homologs of the essential gene are each expressed in different stages of early child development, and mutations in each of these duplicated genes cause different diseases. d. In humans, defects in different homologs of the essential gene cause different loss-of-function diseases due to subfunctionalization. e. The essential gene is lethal in fruit flies, but there is no disease phenotype exhibited in people.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
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In comparison to experimental results from the genetic manipulation of an invertebrate model, what pathologic outcome(s) would suggest that multiple homologs of a disease gene are present in humans?
a. Missing the essential gene homolog that is lethal in fruit flies is also lethal in human infants.
b. Different homologs of the essential gene are each expressed in different human organs, and mutations in these duplicated genes cause organ-specific diseases.
c. Different homologs of the essential gene are each expressed in different stages of early child development, and mutations in each of these duplicated genes cause different diseases.
d. In humans, defects in different homologs of the essential gene cause different loss-of-function diseases due to subfunctionalization.
e. The essential gene is lethal in fruit flies, but there is no disease
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