In each of the following electrophilic substitution reactions (i) as a first step show the “preactivation” or generation of an electrophilic species; (ii) using arrows provide a mechanistic explanation of the course of the reaction (show all resonance structures contributing for intermediatearenium ion stabilization); (iii) write all major products of the reaction. Friedel-Crafts acylation of anisole with 2-methylpropanoyl chloride ((CH3)2-CH-COCl) in the presence of AlCl3 as a catalyst.

In each of the following electrophilic substitution reactions (i) as a first step show the “preactivation” or generation of an electrophilic species; (ii) using arrows provide a mechanistic explanation of the course of the reaction (show all resonance structures contributing for intermediatearenium ion stabilization); (iii) write all major products of the reaction. Friedel-Crafts acylation of anisole with 2-methylpropanoyl chloride ((CH3)2-CH-COCl) in the presence of AlCl3 as a catalyst.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.37P

See similar textbooks

Similar questions

Outline the step-by-step method (initiation, propagation(s), and one termination step) for bromination of 2-bromopropane to produce its major product.
Draw/outline a reasonable and detailed mechanism for the dehydration of 2-methylcyclohexanol catalyzed by phosphoric acid. Use curved arrows to show the flow of electrons and draw the structures of all intermediates and byproducts formed in the reaction. Predict and rationalize the expected product distribution based on thermodynamic aspects
Provide the retrosynthetic analysis for following compounds. Suggest disconnection. Use FGIs if needed. Show the synthons, the charge patterns (where applicable), and the synthetic equivalents (SE). No need to show the forward-synthesis.
Write suitable detailed mechanisms to account for the formation of the products in the following reactions, with arrows and proper stochiometry. Show all intermediates and any by products that are formed in these reactions.
During the dehydration of alcohols, either of concentrated sulfuric or phosphoric acid is often used. If the purpose of the acid is to provide a proton for catalysis, then why can one not use concentrated hydrochloric acid? Please explain fully including reaction mechanisms and resonance.
Which of the following is statements is/are TRUE about the experiment on the relative rates of electrophilic aromatic substitution?I. The experiment must be performed in dark conditions. II. Using the same solvents, a faster decolorization will be observed in aniline as compared to ethylbenzene. III. Chlorobenzene will react faster than methoxybenzene. IV. The use of AlCl3 in the halogenation of aromatic compounds using elemental bromine could hasten the reaction.
organic synthesis of Terephthalic acid from benzene, provide schemes/ figures of the synthesis structure
How are cyclopropanes synthesized from alkenes using carbene reactants and how is the mechanism understood to predict the products. Also, what are the various methods for generating carbenes (including the preparation of Simmons-Smith reagents)
In each of the following electrophilic substitution reactions (i) as a first step show the“preactivation” or generation of an electrophilic species; (ii) using arrows provide a mechanisticexplanation of the course of the reaction (show all resonance structures contributing for intermediatearenium ion stabilization); (iii) write all major products of the reaction Friedel-Crafts monoalkylation of 1,3-dimethylbenzene with tert-butyl chloride in thepresence of FeCl3 as a catalyst.
Give the structure of the product and/or intermediates of the following reactions. Indicate, where appropriate, both regiochemistry and stereochemistry.
State the detailed reaction scheme and mechanism of the following reaction
Give a clear handwritten answer...give the mechanism of given bleow reactions