In lecture we discussed how a measurement of linkage disequilibrium (D- the disequilibrium coefficient) can be determined by a recursive equation: Dt+1= (1-r) Dt Here r is the frequency of recombination between two loci. This can be related to the physical distance between two loci. We can also re-write this relationship as follows: Dt = (1-r) Do Which allows us to determine the value of D at time t from the starting value of D (Do). This result tells us the disequilibrium will decay over time to zero if nothing else but recombination is occurring.
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
Using Excel produce a plot that shows the decay of D over time (for 50 generations) for four different recombination frequencies: r = 0.5 (independent assortment) r = 0.25 r = 0.1 r = 0.01
*show graph and plot *
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