Transferrin is a blood protein that is encoded by the transferrin locus (Trf). In house mice, the two alleles at this locus (Trf and TrP) are codominant and encode three types of transferrin: Genotype Phenotype Trf / Trf Trf / TrP Trp / Trp Trf-a Trf-ab Trf-b The dilution locus, found on the same chromosome, determines whether the color of a mouse is diluted or full; an allele for dilution (d) is recessive to an allele for full color (d"): Genotype Phenotype d* d* d* (full color) d* (full color) d* d dd d (dilution) Donald Shreffler conducted a series of crosses to determine the map distance between the transferrin locus and the dilution locus (D. C. Shreffler. 1963. Journal of Heredity 54:127-129). The following table presents a series of crosses carried out by Shreffler and the progeny resulting from these crosses. Progeny phenotypes dt D+ Cross ở Trf-ab Trf-b Trf-ab Trf-b Total d* Trf" d Trf d Trfb 32 3 21 62 d Trft d Trf" d Trfb dt Trf" 16 38 d Trfb d* Trf" 3 d Trfh 35 9. 4 30 78 d Trf d Trf d Trf d Trf d* Trf" 21 3 2 19 45 d Trf d' Trf d Trf" d Trf d Trf d* Trf" d Trf" 29 22 64 d Trft 6. d Trf 4 14 11 0 29 20

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