Under basic conditions, in nucleophilic acyl substitution,O protonation of the carbonyl group is followed by nucleophilic attack.loss of the leaving group is followed by formation of an acylium ion.an SN2 mechanism is followed.the nucleophile must be a weaker base than the leaving group.O nucleophilic addition to the carbonyl is followed by loss of a leaving group.

In this question we have to choose correct option of the under basic conditions, in nucleophilic…

Answered: in nucleophilic acyl substitution,

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Chemistry

in nucleophilic acyl substitution,

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter24: Amines And Heterocycles

Section24.SE: Something Extra

Problem 42MP

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Concept explainers

Aldehydes and Ketones

Aldehydes and ketones are organic compounds that have a carbonyl group, C = O, as their functional group. They both differ in the placement of this carbonyl group in their structures.

Question

Under basic conditions, in nucleophilic acyl substitution,
O protonation of the carbonyl group is followed by nucleophilic attack.
loss of the leaving group is followed by formation of an acylium ion.
an SN2 mechanism is followed.
the nucleophile must be a weaker base than the leaving group.
O nucleophilic addition to the carbonyl is followed by loss of a leaving group.

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