In order for fatty acids to enter the mitochondria to be catabolized via β-oxidation, they must first be reacted with coenzyme A (reaction ①). Use the equations below to answer parts a-c. ① Fatty Acid + CoA → Fatty Acid—CoA ΔG = ??? ② ATP → AMP + PPi ΔG = ─45.6 kJ/mol ③ PPi → 2 Pi ΔG = ─19.2 kJ/mol ④ Fatty Acid + ATP + CoA → FA—CoA + AMP + 2 Pi ΔG = ─34 kJ/mol a) Calculate ΔG for reaction 1. b) Suppose the formation of the fatty acid--CoA proceeded via the reaction of ATP to ADP instead of AMP. Calculate ΔG for reaction 5. ① Fatty Acid + CoA → Fatty Acid—CoA ΔG = from part a ② ATP → ADP + Pi ΔG = ─30.5 kJ/mol ⑤ Fatty Acid + ATP + CoA → FA—CoA + ADP + Pi ΔG = ??? kJ c) So why does the reaction proceed involving AMP rather than ADP? Your answer should include more than just a numerical reason.
In order for fatty acids to enter the mitochondria to be catabolized via β-oxidation, they must first be reacted with coenzyme A (reaction ①). Use the equations below to answer parts a-c.
① Fatty Acid + CoA → Fatty Acid—CoA ΔG = ???
② ATP → AMP + PPi ΔG = ─45.6 kJ/mol
③ PPi → 2 Pi ΔG = ─19.2 kJ/mol
④ Fatty Acid + ATP + CoA → FA—CoA + AMP + 2 Pi ΔG = ─34 kJ/mol
a) Calculate ΔG for reaction 1.
b) Suppose the formation of the fatty acid--CoA proceeded via the reaction of ATP to ADP instead of AMP. Calculate ΔG for reaction 5.
① Fatty Acid + CoA → Fatty Acid—CoA ΔG = from part a
② ATP → ADP + Pi ΔG = ─30.5 kJ/mol
⑤ Fatty Acid + ATP + CoA → FA—CoA + ADP + Pi ΔG = ??? kJ
c) So why does the reaction proceed involving AMP rather than ADP? Your answer should include more than just a numerical reason.
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