In the Nernst equation [V = 62 log10 (Co / Ci)], the term Co represents: cell bio the intracellular concentration of calcium the extracellular concentration of potassium the extracellular concentration of sodium the intracellular concentration of potassium the membrane potential (in millivolts)
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In the Nernst equation [V = 62 log10 (Co / Ci)], the term Co represents: cell bio
- the intracellular concentration of calcium
- the extracellular concentration of potassium
- the extracellular concentration of sodium
- the intracellular concentration of potassium
- the membrane potential (in millivolts)
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- One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?In the Nernst equation [V = 62 log10 (Co/ Ci)], the term Co represents: the intracellular concentration of potassium the intracellular concentration of chloride the membrane potential (in millivolts) the extracellular concentration of sodium the extracellular concentration of potassiumIn the Nernst equation [V = 62 log10 (Co/ Ci)], the term Co represents: the intracellular concentration of calcium the extracellular concentration of potassium the extracellular concentration of sodium the intracellular concentration of potassium the membrane potential (in millivolts)
- You have a semi permeable membrane with a membrane potential of -90mV. You also have two ions that are both permeable to the membrane, Na and Cl. Na has a concentration of 10mM inside the membrane and 120mM outside the membrane. Cl has a concentration of 1.5mM inside the membrane and 77.5mM outside the membrane. Use the nernst equation to calculate the electrochemical equilibrium of both ions, and show in which direction the netflux would be for each ion.The equilibrium potential for a given ion (Eion) is a theoretical value. For a given concentration gradient of an ion, the equilibrium potential is the charge inside the cell required to hold an ion at that concentration. That is, it is the charge required to perfectly oppose the drive of the ion to move down its concentration gradient. So, if the concentration of Nat is higher outside the cell than inside, its equilibrium potential (ENa) must be I and if we add more sodium to the extracellular fluid, then ENa will II.Calculate the energy required for, or released in, a transport of 20 Na+ ions and of 100 molecules of glucose into a biological cell at 37 oC if the membrane potential is –50 mV (negative inside the cell), the concentrations of Na+ and glucose inside the cell are 0.001mol L-1 and 0.01mol L-1 consequently and the concentrations of Na+ and glucose outside of the cell are 0.1mol L-1 and 0.001mol L-1 consequently.
- Calculate the maximum ratio that can be achieved by the plasma membrane Na+-glucose symporter of an epithelial cell when [Na+]in is 12 mM, [Na+]out is 145 mM, the membrane potential is −50 mV (inside negative), and the temperature is 37 °C.In the Nernst equation [V = 62 log10 (Co/ Ci)], the term Ci represents: the extracellular concentration of potassium the extracellular concentration of sodium the membrane potential (in millivolts) the intracellular concentration of calcium the intracellular concentration of potassium Which of the following ions must be kept to very low concentrations within the cell cytoplasm in order to allow for enough substrate molecules to synthesize nucleotides and nucleic acids? HCO3- (bicarbonate) Ca2+ (calcium) PO43- (phosphate) Na+ (sodium) K+ (potassium)If the equilibrium potential for K* is -90mV, and the charge inside the cell is -70mV, which direction will K move across the membrane assuming there is permeability (membrane leak channels) which allow it to pass?
- if an object b has a plasma sodium concentration of 135mOsm/L and an intracellular concentration of 4mOsm/L. It also has a plasma concentration of potassium of 20mOsm/L and an intracellular concentration of 200mOsm/L. studies identify that the cells have a permeability to potassium that is 10 times greater than sodium. What is the resting membrane potentialCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane permeable only to Cl−.