In what disease is a decrease in sphingomyelin observed?
Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter7: Basic Clinical Microbiology
Section7.5: Tests For Group A Streptococcus
Problem 4RQ
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In what disease is a decrease in sphingomyelin observed?
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Sphingomyelin, type of sphingolipid found in the cell membrane of animal cells, especially in the myelin sheath that surrounds nerve cell axons. Sphingomyelin consists of a phosphocholine head group, sphingosine, and fatty acid and not from the glycerol head group. This composition of sphingomyelin plays important roles such as synthesis and degradation to produce secondary messengers in signaling pathways. These are synthesized involves the enzymatic transfer of phosphocholine from phosphatidylcholine to ceramide.
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