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incidence rate ratio comparing the four categories of Any hormonal contraception (<1 yr, 1 to <5 yr, 5 to 10 yr, >10 yr) and Never used hormonal contraception

incidence rate ratio comparing the four categories of Any hormonal contraception (<1 yr, 1 to <5 yr, 5 to 10 yr, >10 yr) and Never used hormonal contraception

Nutrition Through The Life Cycle
Nutrition Through The Life Cycle
7th Edition
ISBN:9781337919333
Author:Brown, Judith E.
Publisher:Brown, Judith E.
Chapter3: Preconception Nutrition- Conditions And Interventions
Section: Chapter Questions
Problem 6RQ
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Calculate incidence rate ratio comparing the four categories of Any hormonal contraception (<1 yr, 1 to <5 yr, 5 to 10 yr, >10 yr) and Never used hormonal contraception. Use the Never used hormonal contraception group as a reference and use the age-adjusted incidence rates 

Variable Never used hormonal contraception Used hormonal contraception >6 mo previously Duration of current or recent use of hormonal contraception Any hormonal contraception <1 yr 1 to <5 yr 5 to 10 yr >10 yr Combined oral contraceptives <1 yr 1 to <5 yr 5 to 10 yr >10 yr Time since most recent use of hormonal contraception Any hormonal contraception <1 yr 1 to <5 yr 5 to 10 yr >10 yr Combined oral contraceptives <1 yr 1 to <5 yr 5 to 10 yr >10 yr No. of Person-Yr 7,815,180 4,348,722 7,308,437 1,170,657 3,339,451 2,118,912 679,417 6,424,088 1,084,435 2,980,688 1,808,425 550,540 1,039,247 1,989,435 983,689 341,657 1,032,653 2,169,364 1,174,457 431,393 No. of Breast- Cancer Events 5955 2883 2679 266 909 899 605 1935 194 603 652 486 455 1152 859 417 400 1166 1026 524 Age-Adjusted Incidence Rate no. of events/ 100,000 person-yr 55 58 68 58 64 69 74 68 54 64 70 76 60 57 58 58 60 56 60 62 Adjusted Relative Risk (95% CI)* 1.00 (Reference) 1.08 (1.03 to 1.13) 1.20 (1.14 to 1.26) 1.09 (0.96 to 1.23) 1.18 (1.10 to 1.27) 1.24 (1.15 to 1.34) 1.38 (1.26 to 1.51) 1.19 (1.13 to 1.26) 1.03 (0.89 to 1.19) 1.17 (1.07 to 1.27) 1.27 (1.16 to 1.38) 1.46 (1.32 to 1.61) 1.09 (0.99 to 1.29) 1.03 (0.96 to 1.10) 1.04 (0.97 to 1.12) 1.08 (0.97 to 1.20) 1.05 (0.95 to 1.17) 1.00 (0.93 to 1.06) 1.05 (0.98 to 1.13) 1.05 (0.96 to 1.16) P Value 0.002 <0.001 0.73 0.55 Age-Adjusted Risk Difference (95% CI) no. of events/ 100,000 person-yr Reference 3 (1 to 6) 13 (10 to 16) 3 (-5 to 10) 9 (4 to 13) 14 (9 to 19) 19 (13 to 25) 13 (10 to 17) -1 (-8 to 8) 9 (3 to 14) 15 (8 to 21) 21 (14 to 28) 5 (-1 to 11) 2 (-2 to 5) 3 (-1 to 7) 3 (-3 to 4) 5 (-2 to 12) 1 (-3 to 4) 5 (1 to 9) 7 (-1 to 16)
Transcribed Image Text:Variable Never used hormonal contraception Used hormonal contraception >6 mo previously Duration of current or recent use of hormonal contraception Any hormonal contraception <1 yr 1 to <5 yr 5 to 10 yr >10 yr Combined oral contraceptives <1 yr 1 to <5 yr 5 to 10 yr >10 yr Time since most recent use of hormonal contraception Any hormonal contraception <1 yr 1 to <5 yr 5 to 10 yr >10 yr Combined oral contraceptives <1 yr 1 to <5 yr 5 to 10 yr >10 yr No. of Person-Yr 7,815,180 4,348,722 7,308,437 1,170,657 3,339,451 2,118,912 679,417 6,424,088 1,084,435 2,980,688 1,808,425 550,540 1,039,247 1,989,435 983,689 341,657 1,032,653 2,169,364 1,174,457 431,393 No. of Breast- Cancer Events 5955 2883 2679 266 909 899 605 1935 194 603 652 486 455 1152 859 417 400 1166 1026 524 Age-Adjusted Incidence Rate no. of events/ 100,000 person-yr 55 58 68 58 64 69 74 68 54 64 70 76 60 57 58 58 60 56 60 62 Adjusted Relative Risk (95% CI)* 1.00 (Reference) 1.08 (1.03 to 1.13) 1.20 (1.14 to 1.26) 1.09 (0.96 to 1.23) 1.18 (1.10 to 1.27) 1.24 (1.15 to 1.34) 1.38 (1.26 to 1.51) 1.19 (1.13 to 1.26) 1.03 (0.89 to 1.19) 1.17 (1.07 to 1.27) 1.27 (1.16 to 1.38) 1.46 (1.32 to 1.61) 1.09 (0.99 to 1.29) 1.03 (0.96 to 1.10) 1.04 (0.97 to 1.12) 1.08 (0.97 to 1.20) 1.05 (0.95 to 1.17) 1.00 (0.93 to 1.06) 1.05 (0.98 to 1.13) 1.05 (0.96 to 1.16) P Value 0.002 <0.001 0.73 0.55 Age-Adjusted Risk Difference (95% CI) no. of events/ 100,000 person-yr Reference 3 (1 to 6) 13 (10 to 16) 3 (-5 to 10) 9 (4 to 13) 14 (9 to 19) 19 (13 to 25) 13 (10 to 17) -1 (-8 to 8) 9 (3 to 14) 15 (8 to 21) 21 (14 to 28) 5 (-1 to 11) 2 (-2 to 5) 3 (-1 to 7) 3 (-3 to 4) 5 (-2 to 12) 1 (-3 to 4) 5 (1 to 9) 7 (-1 to 16)
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