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- Radiolabeling with 14C-Glutamate Describe the labeling pattern that would result from the introduction into the TCA cycle of glutamate labeled at Cy with 14C.The metabolic precursor for the production of most eicosanoids isDefine the following terms:a. prenylationb. steroidc. digitalisd. lipoproteine. apolipoprotein
- Individuals with inadequate tyrosine metabolism are oftenlight-sensitive and easily develop severe cases of sunburn.Explain. [Hint: The skin pigment melanin is derived froml-DOPA.]The formation of the acyl-enzyme complex in chymotrypsin is through a ------------- reaction between.The amino acids glutamine and glutamate are central toamino acid metabolism. Explain.
- The synthesis of phosphatidylcholine from phosphatidylethanolamine requires: a. Tetrahydrofolate b. Glycine c. Choline d. S-AdenosylmethionineTwo steps in the synthesis of tadalafil, a drug sold under the trade nameCialis for the treatment of erectile dysfunction, are shown. Identifyintermediate A, and draw a mechanism for the conversion of A totadalafil.The peroxisomal enzyme b-ketoacyl–CoA-thiolase does notbind medium-chain acyl-CoA, in contrast to the analogousmitochondrial enzyme. Explain why this phenomenon is anadvantage to the cell.