Malate is converted to oxaloacetate by the enzyme malate dehydrogenase in the final reaction of the citrate cycle. This redox reaction results in the reduction of NAD+ to generate NADH + H+. Answer the three questions below and choose the correct answer. (a) Calculate the delta AE" for the malate dehydrogenase reaction. (b) Calculate AG* and determine if the conversion from malate to oxaloacetate is favorable under standard biochemical conditions using the information below. (c) Under cellular conditions is the AG favorable or unfavorable? Oxaloacetate + 2H* + 2e- --> Malate E - -0.17 V NAD* + H+ + 2e- --> NADH E = -0.32 V

Malate is converted to oxaloacetate by the enzyme malate dehydrogenase in the final reaction of the citrate cycle. This redox reaction results in the reduction of NAD+ to generate NADH + H+. Answer the three questions below and choose the correct answer. (a) Calculate the delta AE" for the malate dehydrogenase reaction. (b) Calculate AG* and determine if the conversion from malate to oxaloacetate is favorable under standard biochemical conditions using the information below. (c) Under cellular conditions is the AG favorable or unfavorable? Oxaloacetate + 2H* + 2e- --> Malate E - -0.17 V NAD* + H+ + 2e- --> NADH E = -0.32 V

Chemistry & Chemical Reactivity

10th Edition

ISBN:9781337399074

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter24: Biochemistry

Section: Chapter Questions

Problem 34GQ: The first step of the metabolic process known as glycolysis is the conversion of glucose to glucose-...

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