Many drugs are either weak acids or weak bases. Acetaminophen is a weak base, the acid form of which has pKa=9.5. Estimate the ration of (protonated/deprotonated) acetaminophen in each of the physiologic environment below: a. Stomach (pH ~ 2.0) b. Small intestine (pH ~ 8.0) c. Venous blood (pH ~ 7.35)

Many drugs are either weak acids or weak bases. Acetaminophen is a weak base, the acid form of which has pKa=9.5. Estimate the ration of (protonated/deprotonated) acetaminophen in each of the physiologic environment below: a. Stomach (pH ~ 2.0) b. Small intestine (pH ~ 8.0) c. Venous blood (pH ~ 7.35)

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter20: Carboxylic Acids And Nitriles

Section20.3: Biological Acids And The Henderson–hasselbalch Equation

Problem 5P: Calculate the percentages of dissociated and undissociated forms present in the following solutions:...

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