If you may please help me with evidence and the explanation of the chart in 1700–1800. The other years aren't neccessary but thank you. E.L. Trudeau was quick to distinguish between a helpful therapy and a cure. He opened the AdirondackCottage Sanitarium, where poor and rich alike could come and receive the benefits of fresh air, plenty ofsunlight, rest, and abundant but simple nourishing food. Hundreds benefited. Similar institutionsopened up in the U.S., and the movement was already well underway in Western Europe. But the curewould only come in the 1950s with the discovery of antibiotics that were effective against themycobacterium.QuestionsChoose ONE of the following questions for your group to answer. Some outside research willbe required - you will have to find an additional resource to help you answer this question.Your answer must include at least one direct quote from this resource. In addition, write anevaluation of the resource that you choose: how did you find it? Who wrote theinformation, and on what is it based? What makes it a reliable resource?Question 1:The curve shown in Figure 2 has three parts,from 1700-1800, 1800 to approx. 1955, and1955 to approximately 1985. The data used toproduce the curve are from Western Europe,but a similar one could be expected for theUnited States. From what you know of thehistory and culture of the United States andWestern Europe, write a paragraph tellingwhy each part of the curve looks the way itdoes. In looking just at this graph, what wouldyou predict about the death rate from TB in2000 and 2005?Death rate per 100,000100050010050+10-5-10.51700 1750 1800 1850 1900 1950Year2000Figure 2: Western European mortality statistics-TB deaths over time (Based on Murray, 2001).In recent years, a combination of developmentof antibiotic resistant strains of MTb alongwith the creation of a reservoir of immunocompromised people by the worldwide AIDS epidemic havecontributed to a resurgence of tuberculosis in the United States and a worldwide upswing in TB casesand deaths. This resurgence has been accompanied by a resurgence of interest in the disease byscientists asking new questions about the nature of true host genetic susceptibility/resistance genes fortuberculosis, about virulence genes within the mycobacterium itself which might offer new drug targets,and about the epigenetic factors that may influence disease predisposition and outcome in people withtuberculosis. Dr. Trudeau had followed Dr. Koch's work with interest. He worked hard to learn how to culture MTborganisms, and was the first to do so in the United States. Intrigued by the correlation between healthyoutdoor lifestyle and efficient anti-tubercular defense in his own case, he devised a simple experiment.The experiment spoke to both the MTb "germ" as sole causative agent of tuberculosis and a possibletherapy for the disease. The experiment was described in his 1886 paper, "Environment in its Relation tothe Progress of Bacterial Invasion in Tuberculosis." The following is an excerpt from that paper:First. What results ensue when both bacillary infection and unhygienic surroundings are madeto coexist in tuberculosis?Second. Are unhygienic surroundings when every known precaution has been taken to excludethe bacillus sufficient of themselves to bring about the disease?Third. Is bacillary infection invariably progressive in animals placed under the best conditions ofenvironment attainable?Experiments.-Fifteen rabbits were made use of and divided in three lots, each set of animalsbeing placed under conditions best adapted to answer in the results noted [in] the threequestions already referred to.Experiment No. 1. Five rabbits were inoculated in the right lung and in the left side of the neckwith five minims of sterilized water in which was suspended a sufficient quantity of a pureculture (third generation) of the tubercle bacillus to render the liquid quite perceptibly turbidThe needle of the Koch's inoculating syringe was inserted subcutaneously on the left side of theneck and in the third intercostal space to a depth of thirty millimetres on the right side. Theseanimals were then confined in a small box and put in a dark cellar. They were thus deprived oflight, fresh air and exercise and were also stinted in the quantity of food given them while beingthemselves artificially infected with the tubercle bacillus.Experiment No. 2. Five healthy rabbits were placed under the following conditions: A fresh holeabout ten feet deep was dug in the middle of a field, and the animals having been confined in asmall box with high sides but no top, were lowered to the bottom of this pit, the mouth ofwhich was then covered with boards and fresh earth. Through this covering a small trap doorwas cut which was only opened long enough each day to allow of the food, consisting of a smallpotato to each rabbit, being thrown to the animals. So damp was the ground at the bottom ofthis pit that the box in which the rabbits were confined was constantly wet. Thus these animalswere deprived of light, fresh air, and exercise, furnished with but a scanty supply of food whilebreathing a chill and damp atmosphere, though free from disease themselves and removed asfar as possible from any accidental source of bacterial infection.Experiment No. 3. Five rabbits having been inoculated in precisely the same manner as theanimals in the first experiment, were at once turned loose on a small island in June, 1886. Itwould be difficult to imagine conditions better suited to stimulate the vitality of these animalsto the highest point than were here provided. They lived all the time in the sunshine and freshair, and soon acquired the habit of constant motion so common in wild animals. The grass andgreen shrubs on the island afforded all the fresh food necessary and in addition they were dailyprovided with an abundant supply of vegetables. Thus, while artificially infected themselvesthey were placed in the midst of conditions well adapted to stimulate their vital powers to thehighest point attainable.

Name: If you may please help me with evidence and the explanation of the cha
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Description: If you may please help me with evidence and the explanation of the chart in 1700–1800. The other years aren't neccessary but thank you. E.L. Trudeau was quick to distinguish between a helpful therapy and a cure. He opened the AdirondackCottage Sanita

Question

If you may please help me with evidence and the explanation of the chart in 1700–1800. The other years aren't neccessary but thank you. E.L. Trudeau was quick to distinguish between a helpful therapy and a cure. He opened the AdirondackCottage Sanitarium, where poor and rich alike could come and receive the benefits of fresh air, plenty ofsunlight, rest, and abundant but simple nourishing food. Hundreds benefited. Similar institutionsopened up in the U.S., and the movement was already well underway in Western Europe. But the curewould only come in the 1950s with the discovery of antibiotics that were effective against themycobacterium.QuestionsChoose ONE of the following questions for your group to answer. Some outside research willbe required - you will have to find an additional resource to help you answer this question.Your answer must include at least one direct quote from this resource. In addition, write anevaluation of the resource that you choose: how did you find it? Who wrote theinformation, and on what is it based? What makes it a reliable resource?Question 1:The curve shown in Figure 2 has three parts,from 1700-1800, 1800 to approx. 1955, and1955 to approximately 1985. The data used toproduce the curve are from Western Europe,but a similar one could be expected for theUnited States. From what you know of thehistory and culture of the United States andWestern Europe, write a paragraph tellingwhy each part of the curve looks the way itdoes. In looking just at this graph, what wouldyou predict about the death rate from TB in2000 and 2005?Death rate per 100,000100050010050+10-5-10.51700 1750 1800 1850 1900 1950Year2000Figure 2: Western European mortality statistics-TB deaths over time (Based on Murray, 2001).In recent years, a combination of developmentof antibiotic resistant strains of MTb alongwith the creation of a reservoir of immunocompromised people by the worldwide AIDS epidemic havecontributed to a resurgence of tuberculosis in the United States and a worldwide upswing in TB casesand deaths. This resurgence has been accompanied by a resurgence of interest in the disease byscientists asking new questions about the nature of true host genetic susceptibility/resistance genes fortuberculosis, about virulence genes within the mycobacterium itself which might offer new drug targets,and about the epigenetic factors that may influence disease predisposition and outcome in people withtuberculosis. Dr. Trudeau had followed Dr. Koch's work with interest. He worked hard to learn how to culture MTborganisms, and was the first to do so in the United States. Intrigued by the correlation between healthyoutdoor lifestyle and efficient anti-tubercular defense in his own case, he devised a simple experiment.The experiment spoke to both the MTb &#34;germ&#34; as sole causative agent of tuberculosis and a possibletherapy for the disease. The experiment was described in his 1886 paper, &#34;Environment in its Relation tothe Progress of Bacterial Invasion in Tuberculosis.&#34; The following is an excerpt from that paper:First. What results ensue when both bacillary infection and unhygienic surroundings are madeto coexist in tuberculosis?Second. Are unhygienic surroundings when every known precaution has been taken to excludethe bacillus sufficient of themselves to bring about the disease?Third. Is bacillary infection invariably progressive in animals placed under the best conditions ofenvironment attainable?Experiments.-Fifteen rabbits were made use of and divided in three lots, each set of animalsbeing placed under conditions best adapted to answer in the results noted [in] the threequestions already referred to.Experiment No. 1. Five rabbits were inoculated in the right lung and in the left side of the neckwith five minims of sterilized water in which was suspended a sufficient quantity of a pureculture (third generation) of the tubercle bacillus to render the liquid quite perceptibly turbidThe needle of the Koch's inoculating syringe was inserted subcutaneously on the left side of theneck and in the third intercostal space to a depth of thirty millimetres on the right side. Theseanimals were then confined in a small box and put in a dark cellar. They were thus deprived oflight, fresh air and exercise and were also stinted in the quantity of food given them while beingthemselves artificially infected with the tubercle bacillus.Experiment No. 2. Five healthy rabbits were placed under the following conditions: A fresh holeabout ten feet deep was dug in the middle of a field, and the animals having been confined in asmall box with high sides but no top, were lowered to the bottom of this pit, the mouth ofwhich was then covered with boards and fresh earth. Through this covering a small trap doorwas cut which was only opened long enough each day to allow of the food, consisting of a smallpotato to each rabbit, being thrown to the animals. So damp was the ground at the bottom ofthis pit that the box in which the rabbits were confined was constantly wet. Thus these animalswere deprived of light, fresh air, and exercise, furnished with but a scanty supply of food whilebreathing a chill and damp atmosphere, though free from disease themselves and removed asfar as possible from any accidental source of bacterial infection.Experiment No. 3. Five rabbits having been inoculated in precisely the same manner as theanimals in the first experiment, were at once turned loose on a small island in June, 1886. Itwould be difficult to imagine conditions better suited to stimulate the vitality of these animalsto the highest point than were here provided. They lived all the time in the sunshine and freshair, and soon acquired the habit of constant motion so common in wild animals. The grass andgreen shrubs on the island afforded all the fresh food necessary and in addition they were dailyprovided with an abundant supply of vegetables. Thus, while artificially infected themselvesthey were placed in the midst of conditions well adapted to stimulate their vital powers to thehighest point attainable.

Accepted Answer

Tuberculosis is a deadly disease caused by the bacterium mycobacterium tuberculosis which is a rod…

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