Macroscale and Microscale Organic Experiments
7th Edition
ISBN:9781305577190
Author:Kenneth L. Williamson, Katherine M. Masters
Publisher:Kenneth L. Williamson, Katherine M. Masters
Chapter20: Bromination And Debromination: Purification Of Cholesterol
Section: Chapter Questions
Problem 4Q
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Organomagnesium compounds
The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.
Hydrolysis Grignard Reactions and Reduction
Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.
Question
Devise a synthesis of anastrozole, a drug used to reduce the recurrence of breast cancer, from the given compounds. You may use any other needed organic compounds or inorganic reagents.
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