Organomagnesium compounds
The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.
Hydrolysis Grignard Reactions and Reduction
Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.
Propranolol, an antihypertensive agent used in the treatment of high blood pressure, can be prepared from 1-naphthol, epichlorohydrin, and isopropylamine using two successive nucleophilic substitution reactions. Devise a stepwise synthesis of propranolol from these starting materials.
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